Regulatory role of PI3K/AKT pathway in diabetic retinopathy

VernacularTitle:PI3K/AKT通路在糖尿病视网膜病变中的调控作用
Author: Baohua LI ¹ ; Zefeng KANG ¹ ; Xinyue HOU ¹ ; Jianquan WANG ¹ ; Man SONG ¹ ; Danyu LI ¹ ; Mengyu LIU ¹ ; Xin YAN ¹
Author Information

1. Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China
Publication Type:Journal Article
Keywords: PI3K/AKT pathway; diabetic retinopathy; neurodegenerative disease; microangiopathy
From: International Eye Science 2024;24(9):1426-1431
CountryChina
Language:Chinese
Abstract: Diabetic retinopathy(DR)is one of the major complications of diabetes mellitus, characterized by neurodegeneration and microangiopathy. Currently, the treatment of DR is mainly focused on the management of late complications and has not achieved the desired clinical outcome. Evidence suggests that the PI3K/AKT pathway, as one of the important intracellular signaling pathways during the cell cycle, is involved in the whole process of DR pathogenesis. This article focuses on the structural composition, activation and blocking pathways, conduction pathways, regulatory mechanisms and biological functions of the PI3K/AKT signaling pathway to review its role in DR and to explore the potential of targeting the PI3K/AKT pathway for the treatment of DR.