Advances in the role of programmed cell death in retinal ganglion cells in glaucoma

VernacularTitle:程序性细胞死亡在青光眼视网膜神经节细胞中的研究进展
Author: Shiyi SONG ^{1
,

2
,

3} ; Liang LIANG ^{1
,

2
,

3}
Author Information

1. First College of Clinical Medical Science, China Three Gorges University
2. the Institute of Ophthalmology and Visual Science of China Three Gorges University
3. Department of Ophthalmology, Yichang Central People's Hospital, Yichang 443003, Hubei Province, China
Publication Type:Journal Article
Keywords: programmed cell death; glaucoma; retinal ganglion cells; apoptosis; ferroptosis; pyroptosis; autophagy; parthanatos
From: International Eye Science 2024;24(9):1416-1420
CountryChina
Language:Chinese
Abstract: Programmed cell death(PCD)is a unique cell death involving effector molecules, including various forms such as apoptosis, autophagy, and pyroptosis. PCD is involved in many aspects of normal physiological activities in humans, and is closely related to the development of many diseases. Glaucoma is the leading cause of irreversible blindness worldwide. Relevant studies have shown that the development of glaucoma is associated with the abnormal expression of a variety of PCD-related proteins. The mechanism and interplay of apoptosis, autophagy, pyroptosis, ferroptosis and parthanatos of retinal ganglion cells in the course of glaucoma were reviewed, to provide a new direction for the prevention treatment of glaucoma.