Consideration and discussion on extinction of influenza B/Yamagata virus and switch of vaccine strain
10.13200/j.cnki.cjb.004277
- VernacularTitle:乙型流感病毒Yamagata系毒株的消失及其疫苗株更换的思考及讨论
- Author:
XIN Li
- Publication Type:Journal Article
- Keywords:
Influenza B virus;
Yamagata lineage;
Vaccine strain
- From:
Chinese Journal of Biologicals
2024;37(8):1014-1019
- CountryChina
- Language:Chinese
-
Abstract:
Influenza B/Yamagata has been circulating in humans for nearly half a century as a seasonal influenza virus. Like other subtypes or lineages of influenza viruses,B/Yamagata lineage virus has continuously mutated and evolved,resulting in multiple clades. In 2014,World Health Organization(WHO)recommended B/Phuket/3073/2013,a representative virus of B/Yamagata lineage 3A group,as a candidate vaccine virus. Since then,the 3A group virus had been the predominant virus of B/Yamagata lineage. Since March 2020,no B/Yamagata lineage virus has been isolated globally. B/Yamagata lineage virus has been probably extinct. Recently,there is a suggestion that WHO should exclude B/Yamagata component from quadrivalent influenza vaccines. This paper reviews the development history of influenza B and its vaccine strains,objectively analyzes the possible causes of the disappearance of B/Yamagata lineage viruses,and comprehensively describes the perspectives of multiple disciplines and departments,including virology,epidemiology,immunology,social sciences related to vaccine immunization and vaccine manufacturers. It makes recommendations on preventing the recurrence of B/Yamagata lineage viruses,and also suggests that policy making authorities and vaccine manufacturers should make plans and preparations for the replacement of quadrivalent vaccine to trivalent vaccine.
