SARS-CoV-2假病毒在生物技术药物有效性评价中的应用进展
10.13200/j.cnki.cjb.004283
- VernacularTitle:Research progress on application of SARS-CoV-2 pseudovirus in biotechnological drug effectiveness evaluation
- Author:
LI Tiantian
- Publication Type:Journal Article
- Keywords:
SARS-CoV-2;
pseudovirus;
Pseudovirus packaging system;
Biotechnological drugs;
Effectiveness
- From:
Chinese Journal of Biologicals
2024;37(8):1008-1013+1019
- CountryChina
- Language:Chinese
-
Abstract:
At present,SARS-CoV-2 is still constantly evolving and mutating,with weakened pathogenicity but faster transmission,which still threatens human health. Anti-SARS-CoV-2 biotechnological drugs are still the hotspot of research and development in the field of biomedicine,and the effectiveness evaluation is very important for screening these drugs. Traditional effectiveness evaluation of anti-SARS-CoV-2 biotechnological drugs requires the live virus of SARS-CoV-2 that is difficult to obtain,and the requirement of high experimental conditions has limited the research and development of anti-SARS-CoV-2biotechnological drugs. SARS-CoV-2 pseudovirus can simulate the infectivity of live virus,but it has no infectivity of live virus,and is safe and easy to prepare,which is a favorable tool for evaluating the effectiveness of SARS-CoV-2 biotechnological drugs. In this paper,the epidemiological characteristics of SARS-CoV-2,the packaging system of SARS-CoV-2 pseudovirus and the application of SARS-CoV-2 pseudovirus in the effectiveness evaluation of biotechnological drugs were reviewed,so as to provide a reference for the application of SARS-CoV-2 pseudovirus in the development and quality evaluation of biotechnological drugs.
