Metabolomics Research in Kidney Transplantation.
10.4285/jkstn.2015.29.2.49
- Author:
Yu Ho LEE
1
;
Sang Ho LEE
Author Information
1. Department of Nephrology, Kyung Hee University College of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
Kidney transplantation;
Metabolomics;
Biological markers
- MeSH:
Biochemistry;
Biomarkers;
Drug-Related Side Effects and Adverse Reactions;
Humans;
Kidney Transplantation*;
Metabolomics*;
Sensitivity and Specificity;
Signal Transduction
- From:The Journal of the Korean Society for Transplantation
2015;29(2):49-53
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute and chronic immune injury, drug toxicity, and cardiovascular complications remain a critical challenge following kidney transplantation. Success from these hurdles is closely associated with the ability to monitor patients and responsively adjust their medication. Metabolic and biochemical profiling (metabolomics) may enable detection of early changes in cell signal transduction regulation and biochemistry with high sensitivity and specificity. However, metabolomics have not been studied extensively in the field of kidney transplantation. This review describes the basic principles of metabolomics, summarizes recent studies, and suggests future perspectives.
