The clinical correlations of gene polymorphism of methylenetetrahydrofolate reductase with Alzheimers disease
10.19405/j.cnki.issn1000-1492.2024.06.026
- Author:
Mengzhe You
1
;
Xia Zhou
2
;
Wenwen Yin
2
;
Ke Wan
2
;
Zhongwu Sun
2
Author Information
1. Dept of Rehabilitation , The Second Afiliated Hospital of Anhui Medical University , Hefei 230601
2. Dept of Neurology , The First Afiliated Hospital of Anhui Medical University , Hefei 230022
- Publication Type:Journal Article
- Keywords:
Alzheimer ′ s disease;
amnestic mild cognitive impairment;
methylenetetrahydrofolate reductase;
ho⁃ mocysteine
- From:
Acta Universitatis Medicinalis Anhui
2024;59(6):1081-1088
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the correlation between the methylenetetrahydrofolate reductase ( MTHFR)
C677T polymorphism and disease in the course of Alzheimer ′ s disease (AD) , as well as whether whether it is affected by APOE gene .
Methods :A total of 74 AD patients , 85 aMCI patients and 81 healthy controls (HC) were included . The levels of serum homocysteine (Hcy) , folate , and vitamin B 12 , as well as the genotypes of MTHFR
C677T and APOE , were determined . Logistic regression analysis was conducted to explore the relationship between MTHFR C677T polymorphism and the risk of AD and aMCI , as well as in different APOE ε4 subgroups .
Results:Compared with HC group , the serum Hcy levels in AD group and aMCI group were significantly higher ( P < 0. 001 , P < 0. 001) , while serum folate levels in aMCI group was significantly lower (P = 0. 017) . The serum folate level was significantly lower (P = 0. 038) in individuals with the MTHFR TT genotype compared to those with CC and CT genotypes , while the serum Hcy level was significantly higher ( P = 0. 002 ) . Regression analysis showed that the MTHFR TT genotype might increase the risk of aMCI in the subgroup of APOE ε4 non⁃carriers ( OR = 3 . 670 , 95% CI = 1 . 077 - 12. 509 , P = 0. 038) , but not in APOE ε4 carriers .
Conclusion:MTHFR C677T polymorphism plays an important role in Hcy metabolism , which leads to increased serum Hcy levels and decreased folate levels . In APOE ε4 non⁃carriers , the MTHFR TT genotype may increase the risk of aMCI .
- Full text:2024082014555534635亚甲基四氢叶酸还原酶基因多...尔茨海默病的相关性临床研究_游孟哲.pdf
