Application of growth hormone pretreatment in preimplantation genetic testing for aneuploidy
10.19405/j.cnki.issn1000-1492.2024.06.012
- VernacularTitle:生长激素预处理在胚胎植入前染色体非整倍体检测中的应用研究
- Author:
Haiyan ZHOU
1
,
2
,
3
;
Caiyun WU
;
Dehuan HUANG
;
Yan HAO
;
Dawei CHEN
;
Menghan WANG
;
Gang ZHAO
;
Ping ZHOU
Author Information
1. 安徽医科大学第一附属医院妇产科,合肥 230032
2. 安徽医科大学附属巢湖医院妇产科,巢湖 238000
3. 国家卫生健康委配子及生殖道异常研究重点实验室,合肥 230032
- Keywords:
growth hormone pretreatment;
preimplantation genetic testing for aneuploidy;
euploid;
pregnancy out-come
- From:
Acta Universitatis Medicinalis Anhui
2024;59(6):988-993
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of growth hormone(GH)pretreatment on the improvement of eu-ploid and pregnancy outcome.Methods A prospective analysis was conducted on 134 patients undergoing preim-plantation genetic testing for aneuploidy(PGT-A),among whom 30 patients were self-controlled and 104 patients were inter-group controlled.According to whether GH was added,the patients were divided into GH pretreatment group and GH non-pretreatment group.GH pretreatment included subcutaneous injection of GH 2U/day for 4-6 weeks before the start of gonadotropin(Gn),and the dose was doubled on the day of Gn until the trigger day.GH non-pretreatment meant no GH treatment,GH pretreatment was given when the previous PGT-A cycle failed within one year when the PGT-A was performed again,forming the self-control group.The basic situation,blastocyst situa-tion and pregnancy outcome were compared between the groups by inter-group and self-control.Results No matter in the group control or self-controlled group,the endometrial thickness on the day of HCG,ovarian sensitivity index(OSI),number of oocytes obtained,MII oocytes,2PN number,2PN fertilization rate,available oocyte rate,num-ber of biopsy blastocysts,number of euploid blastocysts,euploid blastocyst rate,and at least one euploid rate sig-nificantly increased after GH pretreatment,with statistically significant differences(P＜0.05).The total amount of Gn,Gn days,number of mosaic blastocysts,and mosaic blastocyst rate were not significantly changed after GH pretreatment,with no statistically significant differences.The implantation rate and clinical pregnancy rate in-creased after GH pretreatment,but with no statistically significant differences.Conclusion GH pretreatment can significantly improve the number and rate of euploid embryos in patients undergoing PGT-A,and has a tendency to improve pregnancy outcome.
