Application of growth hormone pretreatment in preimplantation genetic testing for aneuploidy
10.19405/j.cnki.issn1000-1492.2024.06.012
- Author:
Haiyan Zhou
1
,
2
,
3
;
Caiyun Wu
1
,
4
,
5
;
Dehuan Huang
1
,
4
,
5
;
Yan Hao
1
,
4
,
5
;
Dawei Chen
1
,
4
,
5
;
Menghan Wang
6
;
Gang Zhao
6
;
Ping Zhou
1
,
3
,
7
Author Information
1. Dept of Obstetrics and Gynecology , The First Afiliated Hospital of Anhui Medical University , Hefei 230032
2. Dept of Obstetrics and Gynecology, Chaohu Afiliated Hospital of Anhui Medical University , Chaohu 238000
3. NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract , Hefei 230032
4. Anhui Province Key Laboratory of Reproductive Health and Genetics , Hefei 230032
5. Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs , Hefei 230032
6. Dept of Electronic Engineering and Information Sciences , University of Science and Technology of China , Hefei 230027
7. Dept of Electronic Engineering and Information Sciences , University of Science and Technology of China
- Publication Type:Journal Article
- Keywords:
growth hormone pretreatment;
preimplantation genetic testing for aneuploidy;
euploid;
pregnancy out⁃ come
- From:
Acta Universitatis Medicinalis Anhui
2024;59(6):988-993
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the effect of growth hormone (GH) pretreatment on the improvement of euploid and pregnancy outcome .
Methods :A prospective analysis was conducted on 134 patients undergoing preimplantation genetic testing for aneuploidy(PGT⁃A) , among whom 30 patients were self⁃controlled and 104 patients were inter⁃group controlled . According to whether GH was added , the patients were divided into GH pretreatment group and GH non⁃pretreatment group . GH pretreatment included subcutaneous injection of GH 2U/day for 4 - 6 weeks before the start of gonadotropin (Gn) , and the dose was doubled on the day of Gn until the trigger day . GH non⁃pretreatment meant no GH treatment , GH pretreatment was given when the previous PGT⁃A cycle failed within one year when the PGT⁃A was performed again , forming the self⁃control group . The basic situation , blastocyst situation and pregnancy outcome were compared between the groups by inter⁃group and self⁃control .
Results :No matter in the group control or self⁃controlled group , the endometrial thickness on the day of HCG , ovarian sensitivity index ( OSI) , number of oocytes obtained , MII oocytes , 2PN number , 2PN fertilization rate , available oocyte rate , number of biopsy blastocysts , number of euploid blastocysts , euploid blastocyst rate , and at least one euploid rate significantly increased after GH pretreatment , with statistically significant differences (P < 0. 05) . The total amount of Gn , Gn days , number of mosaic blastocysts , and mosaic blastocyst rate were not significantly changed after GH pretreatment , with no statistically significant differences . The implantation rate and clinical pregnancy rate increased after GH pretreatment , but with no statistically significant differences .
Conclusion :GH pretreatment can significantly improve the number and rate of euploid embryos in patients undergoing PGT⁃A , and has a tendency to improve pregnancy outcome .
- Full text:2024082010030118059生长激素预处理在胚胎植入前...体非整倍体检测中的应用研究_周海燕.pdf
