Application of melatonin⁃supplemented in vitro maturation technology for human oocytes during COH cycle
10.19405/j.cnki.issn1000-1492.2024.06.011
- Author:
Yu Ren
1
,
2
,
3
,
4
;
Xingxing Han
1
,
4
,
5
,
6
;
Qiqi Zhang
1
,
4
,
5
,
6
;
Lu Liu
7
;
Xiaofeng Xu
1
,
4
,
5
,
6
;
Zhiguo Zhang
1
,
2
,
3
,
4
;
Huijuan Zou
1
,
2
,
3
,
4
Author Information
1. Dept of Obstetrics and Gynecology, The First Afiliated Hospital of Anhui Medical University, Hefei 230032
2. NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract ,Hefei 230032
3. Key Laboratory of Population Health Across Life Cycle ,Ministry of Education of the People s Republic of China , Hefei 230032
4. Engineering Research Center of Biopreservation and Artifical Organs , Ministry of Education , Hefei 230032
5. Anhui Province Key Laboratory of Reproductive Health and Genetics , Hefei 230032
6. Anhui Provincial Institute of Translational Medicine , Hefei 230032
7. Dept of Obstetrics and Gynecology, Feidong County People s Hospital , East of the First Afiliated Hospital of Anhui Medical University, Hefei 231600
- Publication Type:Journal Article
- Keywords:
oocyte;
in vitro maturation technology;
in vitro fertilization;
controlled ovarian hyperstimulation;
pregnancy outcome
- From:
Acta Universitatis Medicinalis Anhui
2024;59(6):983-988
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To compare the early embryonic developmental potential and clinical outcomes of oocytes matured in vivo and those matured by modified in vitro maturation ( LVM ) technology during the same controlled ovarian hyperstimulation ( COH) cycle , and to explore the clinical application of melatonin⁃supplemented IVM
technology.
Methods :159 patients were recruited into the study. 920 mature oocytes were collected during their COH cycles processed for conventional IVF/ICSI protocols , while 1 283 immature oocytes from the same cycles
were matured in a melatonin⁃supplemented IVM medium before ICSI was performed. A retrospective analysis was conducted to compare the impact of conventional assisted reproductive technology and improved IVM technology on the outcomes of assisted reproductive therapy and pregnancy outcomes.
Results :Compared with mature oocytes collected from COH cycles treated with conventional IVF/ICSI , oocytes promoted by improved melatonin⁃supple-mented IVM technology had a lower rate of high⁃quality blastocyst formation. However, after embryo transfer, there was no significant difference in the clinical outcomes of mature oocytes obtained through two methods , including clinical pregnancy rate , full⁃term birth rate , neonatal length , and neonatal Apgar score.
Conclusion :The application of melatonin⁃supplemented IVM significantly increases the utilization of immature oocytes collected from COH cycles , improving the pregnancy outcomes of patients assisted by assisted reproductive technology.
- Full text:202408200955468190补充褪黑素的人卵母细胞体外...熟技术在COH周期中的应用_任宇.pdf
