Research Progress on Methyltransferase-like Protein 3 in Progression of Aerobic Glycolysis in Gastrointestinal Tumors
10.3971/j.issn.1000-8578.2024.24.0045
- VernacularTitle:甲基转移酶样蛋白3在胃肠道肿瘤中参与有氧糖酵解的研究进展
- Author:
Deyuan MA
1
;
Na WANG
2
;
Huiqiang WANG
3
;
Quanlin GUAN
4
Author Information
1. The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China.
2. Department of Oncology, Second Hospital of Lanzhou University, Lanzhou 730000, China.
3. Community Health Service Station of Tai’an Road, People’s Hospital of Rizhao, Rizhao 276827, China.
4. Department of Oncology Surgery, First Hospital of Lanzhou University, Lanzhou 730000, China.
- Publication Type:REVIEWS
- Keywords:
Gastrointestinal Neoplasms;
METTL3;
Glycolysis
- From:
Cancer Research on Prevention and Treatment
2024;51(8):697-702
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic reprogramming is one of the significant characteristics of malignant tumor development. It provides the tumor with sufficient energy and materials. During the process by which tumor cells acquire metabolic reprogramming, epigenetic changes play a crucial role. N6-methyladenosine (m6A) in mRNA is the most common post-transcriptional modification of mRNA. It regulates the transcription, maturation, translation, and degradation of mRNA. Studies have shown that m6A helps promote the metabolic reprogramming of tumor cells. However, the complete mechanism still requires further research. METTL3 is a key enzyme for m6A methylation that catalyzes m6A progression by forming complexes with other proteins, such as METTL14 and WTAP. Notably, the critical role of METTL3 in the metabolic transition of gastrointestinal tumors has not been given due attention. This article summarizes the specific pathways through which METTL3 affects the reprogramming of cellular glucose metabolism in gastrointestinal tumors. We aimed to clarify the importance of METTL3 in the energy reprogramming of gastrointestinal tumors.
