Research Progress on Molecular Mechanism Underlying Chemotherapy Resistance of Malignant Pleural Mesothelioma
10.3971/j.issn.1000-8578.2024.24.0108
- VernacularTitle:恶性胸膜间皮瘤化疗抵抗机制研究进展
- Author:
Li ZHANG
1
;
Jie YU
1
;
Yu CHEN
1
;
Xiaodi LUO
1
;
Jicui WANG
1
;
Dong TU
1
Author Information
1. Department of Cardiothoracic Surgery, the 920th Hospital of Joint Logistics Support Force, Kunming 650032, China.
- Publication Type:REVIEWS
- Keywords:
Malignant pleural mesothelioma;
Chemotherapy resistance;
Molecular mechanism
- From:
Cancer Research on Prevention and Treatment
2024;51(8):690-696
- CountryChina
- Language:Chinese
-
Abstract:
Malignant pleural mesothelioma (MPM) is a rare, highly aggressive, and lethal tumor with poor prognosis. Its survival period ranges from four months to one year, and the 5-year survival rate is only about 10%. MPM is highly resistant to chemotherapy, and conventional treatments such as cisplatin combined with pemetrexed or raltitrexed only have a certain effect in about 20% of patients. In recent years, with the continuous in-depth understanding of the genetic variation characteristics of MPM, some progress has been made in the molecular mechanism underlying the chemotherapy resistance of MPM. This article will summarize the research progress of the molecular mechanism underlying the chemotherapy resistance of MPM, including BAP1 gene mutation, microRNA, MTA1-mediated DNA damage repair pathway, GITR-GITRL pathway, TGFa pathway, tumor stem cell, EGFR, and PTEN. The aim of this work is to provide a reference for exploring new therapeutic targets and combined treatment options for MPM.
