Research Progress on Gene Polymorphisms Related to Osteosarcoma

VernacularTitle:骨肉瘤相关基因多态性的研究进展
Author: Peng ZHANG ^{1
,

2} ; Kai CHEN ; Lingling HUANG ; Jinyan LIU ; Wen TIAN
Author Information

1. 450008 郑州,郑州大学附属肿瘤医院(河南省肿瘤医院)骨与软组织科
2. 450001 郑州,郑州大学公共卫生学院
Keywords: Osteosarcoma; Susceptibility; Single nucleotide polymorphisms; Biomarkers; Genome-wide asso-ciation study
From: Cancer Research on Prevention and Treatment 2024;51(8):625-629
CountryChina
Language:Chinese
Abstract: Osteosarcoma,which primarily affects children and adolescents,is a highly malignant bone tumor with high rates of disability and mortality.Therefore,the exploration of biological markers related to its occurrence,development,and prognosis is crucial.Genome-wide association studies have revealed the vital role of genetic polymorphisms in the pathogenesis of osteosarcoma.This study aims to provide new insights into reliable biomarkers of osteosarcoma through the analysis of the functional single-nucleotide polymor-phisms of tumor-related genes.