Relationship between GRB2 rs8082005 , RXRA rs3849222 and susceptibility to early⁃onset preeclampsia in Yanbian area
10.19405/j.cnki.issn1000-1492.2023.08.026
- Author:
Wanxuan Cai
1
;
Xia Liu
1
;
Guang Jin
1
;
Chunyu Dong
2
;
Enyue Yang
3
Author Information
1. Laboratory of Pathology and Pathophysiology of Yanbian University, Yanji 133002
2. Gynaecology and Obstetrics, Afiliated Hospital of Yanbian University, Yanji 133002
3. Clinical Pharmacology Institute , Afiliated Hospital of Yanbian University, Yanji 133002
- Publication Type:Journal Article
- Keywords:
early⁃onset preeclampsia;
single⁃nucleotide polymorphism;
susceptibility to
- From:
Acta Universitatis Medicinalis Anhui
2023;58(8):1403-1407
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To analyze the association between multiple loci of genes and the risk of early⁃onset pre⁃
eclampsia (EOPE) with pregnancy induced hypertension.
Methods :Among 382 EOPE patients who had lived in Yanbian area for more than 10 years , 192 patients were randomly selected as case group. At the same time , 192 cases of natural delivery in the hospital were randomly selected as the control group. PCR⁃RFLP method was used to determine the specific genotype and allele distribution information , and non⁃conditional Logistic method was used to
obtain odds ratio (OR) and 95% confidence interval (CI) to confirm the risk of various genotypes.
Results :There were two alleles of T and C at the GRB2 rs8082005 locus , TC , TT , and CC genotypes. There were two alleles of T and C at the RXRA rs3849222 locus , TC , TT , and CC genotypes. Through unconditional logistic regression analysis , in the GRB2 rs8082005 locus , compared with the TT genotype , the CC genotype was more susceptible to EOPE ( OR = 3. 155 , 95% CI = 1. 513 - 6. 579 , P = 0. 002) . In the explicit model , compared to patients with TT+ TC genotype , patients with CC genotype increased the risk of EOPE ( OR = 3. 000 , 95% CI = 1. 495 - 6. 022 , P = 0. 002) . In the RXRA rs3849222 locus , compared with the CC genotype , the TT genotype was more susceptible to EOPE ( OR = 2. 031 , 95% CI = 1. 077 - 3. 820 , P = 0. 028) . In the invisible model , compared to patients with CC + CT genotype , patients with TT genotype had an increased risk of EOPE ( OR = 2. 549 , 95% CI = 1. 421 - 4. 573 , P = 0. 002) .
Conclusion :There is a significant correlation between single nucleotide polymorphism (SNP)
at the GRB2 rs8082005 and RXRA rs3849222 loci and the risk of EOPE in pregnant women with gestational hypertension in Yanbian area.
- Full text:2024081910291594653GRB2_rs808200...边地区EOPE易感性的关系_蔡宛轩.pdf
