Serum inflammatory cytokines and Tie⁃2 correlation with clinical symptoms in patients with first⁃episode schizophrenia
10.19405/j.cnki.issn1000-1492.2023.08.024
- Author:
Anzhen Wang
1
,
2
,
3
,
4
,
5
;
Xulai Zhang
1
,
2
,
3
,
4
,
5
;
Fanfan Yan
1
,
2
,
3
,
4
,
5
;
Xiaojing Meng
1
,
2
,
3
,
4
,
5
;
Xialong Cheng
1
,
2
,
3
,
4
,
5
Author Information
1. Afiliated Psychological Hospital of Anhui Medical University, Hefei 230022
2. Anhui Mental Health Center , Hefei 230022
3. Hefei Fourth People &prime
4. s Hospital , Hefei 230022
5. Anhui Clinical Research Center for Mental Disorders , Hefei 230022
- Publication Type:Journal Article
- Keywords:
first⁃episode schizophrenia;
cytokines;
Tie⁃2;
influencing factor
- From:
Acta Universitatis Medicinalis Anhui
2023;58(8):1393-1397
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the differences of serum inflammatory cytokines and tyrosine kinase with immunoglobulin and epidermal growth factor homology domains⁃2(Tie⁃2) levels between patients with first⁃episode schizophrenia and healthy people , and the correlation with clinical symptoms .
Methods :A total of 168 participants were recruited , including 86 patients with first⁃episode schizophrenia (patient group) and 82 healthy people ( control group) . Demographic data , Positive and Negative Symptom Scale (PANSS) and Brief Psychiatric Rating Scale (PANSS) were collected at baseline . Serum inflammatory cytokines and Tie⁃2 levels were determined by MesoScale Discovery (MSD) .
Results :Compared with the control group , the levels of serum interleukin (IL) Ⅳ1β and IL⁃4 in the patient group increased (P < 0. 05) , while the level of Tie⁃2 decreased (P < 0. 05) . IL⁃1β level in the patient group was positively correlated with the total score of BPRS , the score of BPRS hostility factor and the score of PANSS positive scale factor (P < 0. 05) . The positive score of PANSS and the total score of BPRS in the patient group had a positive effect on IL⁃1β level (P < 0. 05) . PANSS negative scale factor score , general psychopathological scale factor score and total score of PANSS in patient group also had positive effects on Tie⁃2 level (P < 0. 05) . IL⁃1β level in the patient group could effectively predict the severity of clinical symptoms in patients with first⁃episode schizophrenia at the critical level of 2 127. 076 pg/L , with specificity of 0. 675 and sensitivity of 0. 639 . The AUC of IL⁃1β and Tie⁃2 were 0. 836 1 and 0. 646 2 , respectively .
Conclusion :The levels of IL⁃1β , IL⁃4 and Tie⁃2 in patients with first⁃episode schizophrenia are different from those in healthy people . IL⁃1β levels in patients with first⁃episode schizophrenia are correlated with part of clinical symptoms . IL⁃1β and Tie⁃2 levels in the patient group may be influencing factors with high sensitivity and specificity in predicting the severity of clinical symptoms in patients with first⁃episode schizophrenia .
- Full text:2024081910183553576血清炎性细胞因子和人血管生...分裂症患者临床症状的相关性_王安珍.pdf
