Characteristics and influencing factors of cognitive impairment in children with attention deficit hyperactivity disorder
10.19405/j.cnki.issn1000-1492.2023.08.023
- Author:
Yuanyuan Huang
1
,
2
;
Qidong Zhu
3
;
Fengchen Wang
4
,
5
;
Feng Geng
6
;
Yulong Zhang
1
,
2
,
7
;
Ling Zhang
8
;
Huanzhong Liu
8
Author Information
1. Chaohu Afiliated Hospital of Anhui Medical University , Hefei 238000
2. Dept of Psychology , The Second Afiliated Hospital of Anhui Medical University, Hefei 230601
3. Dept of Psychology , The Second Afiliated Hospital of Anhui Medical University, Hefei 230601
4. Dept of Pediatric Internal Medicine , Anhui Provincial Children &prime
5. s Hospital , Hefei 230051
6. Dept of Psychology and Sleep Medicine , The Second Afiliated Hospital of Anhui Medical University , Hefei 230601
7. Anhui Psychiatric Center , Anhui Medical University , Hefei 238000
8. Chaohu Afiliated Hospital of Anhui Medical University , Hefei 238000
- Publication Type:Journal Article
- Keywords:
attention deficit and hyperactivity disorder;
cognitive function;
executive function;
clinical symptoms;
influencing factors;
methylphenidate
- From:
Acta Universitatis Medicinalis Anhui
2023;58(8):1387-1392
- CountryChina
- Language:Chinese
-
Abstract:
Objective : The differences of cognitive impairment between children with attention deficit hyperactivity
disorder (ADHD) and normal children were compared , the influencing factors of cognitive impairment of children with ADHD were analyzed .
Methods :A total of 133 children with ADHD were selected as the ADHD group , and 117 normal children were recruited as the control group . The severity of the subjects ′ clinical symptoms was assessed using the Swanson , Nolan , & Pelham Rating Scale⁃Fourth Edition ( SNAP⁃IV) and the Weiss Functional Impairment Rating Scale . The degree of cognitive functional impairment of subjects was assessed using the MATRICS cognitive suite (MCBB) , and the executive function impairment of the subjects was assessed by the Behavior Rating Inventory of Executive Function ( BRIEF) . The differences in cognitive functional impairment of the two groups were compared . The children with ADHD were further divided into three groups according to their clinical phenotype and age , respectively , and the differences of cognitive impairment among the three groups were compared . The influencing factors of the degree of cognitive impairment in children with ADHD were analyzed by multiple linear regression . The improvement of methylphenidate sustained⁃release tablets on cognitive and executive functional impairment in children with ADHD was observed .
Results :The scores of SNAP⁃IV , Weiss Functional Impairment Rating Scale , connection test and BRIEF of ADHD patients were significantly higher than those of normal controls (P < 0. 05) . The scores of symbol coding test and maze test of ADHD patients were significantly lower than those of normal controls (P < 0. 05) . The score of symbol encoding test in children with ADHD⁃HI was significantly higher than that in ADHD⁃I and ADHD⁃C groups (P < 0. 05) , and the total BRIEF score of ADHD⁃C was significantly higher than that in ADHD⁃I and ADHD⁃HI groups (P < 0. 05) . With the increase of age , the score of connection test of ADHD children gradually decreased , while the scores of symbol coding test and maze test gradually increased (P < 0. 05) . The results of multiple linear regression analysis showed that age was the influencing factor of ADHD children ′s score in the connection test , symbol coding test and maze test (P < 0. 05) ; the scores of SNAP⁃IV and Weiss Functional Impairment Rating Scale were the influencing factors of BRIEF score of ADHD children (P < 0. 05) . After methylphenidate treatment , the scores of connection testand BRIEF significantly decreased (P < 0. 001) , while the scores of symbol coding test and maze test significantly increased (P < 0. 001) .
Conclusion :The younger the age and the more serious the clinical symptoms related to ADHD suggest that the cognitive impairment of children with ADHD is more serious . After methylphenidate treatment , the degree of cognitive and executive impairment in children with ADHD are improved .
- Full text:2024081910104676233儿童注意缺陷多动障碍认知功能损害特征及其影响因素_黄媛媛.pdf
