Characteristics of Basal Sex Hormone Levels and Anti-müllerian Hormone Levels in 1221 Women of Different Ages：A Retrospective Study on the Law of Women Reproductive Aging in the "Seven-year Period" Theory
10.13288/j.11-2166/r.2024.13.011
- VernacularTitle:1221例女性基础性激素水平及抗苗勒管激素水平不同年龄段变化特征——女子“以七为期”的生殖衰老规律回顾性研究
- Author:
Wanshi LIANG
1
;
Yiru LIAO
1
;
Jinghan FU
2
;
Luodan HU
1
;
Hongyan YANG
3
;
Jian LIU
3
;
Fangping CHENG
3
;
Guangning NIE
3
Author Information
1. The Second Clinical Medical College of Guangzhou University of Chinese Medicine， Guangzhou， 510405
2. Zhongjing Academy， School of Traditional Chinese Medicine， Henan University of Chinese Medicine
3. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine/ Guangdong Provincial Hospital of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
sex hormones;
anti-müllerian hormone;
reproductive ading;
women;
"seven-year period" theory;
retrospective study
- From:
Journal of Traditional Chinese Medicine
2024;65(13):1369-1374
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the law of women reproductive aging based on theory of "seven-year period" in traditional Chinese medicine（TCM） through analyzing the characteristics of basic sex hormone levels and anti-müllerian hormone levels in women of different ages. MethodsThe data of female who visited Guangdong Provincial Hospital of Traditional Chinese Medicine from January 2018 to December 2022 and accepted basic hormone and anti-müllerian hormone determination were collected retrospectively. According to the age of subjects， they were divided into the "1-2 seven" group （under 21 years old）， "3 seven" group （21-27 years old）， "4 seven" group （28-34 years old）， "5 seven" group （35-41 years old）， "6 seven" group （42-48 years old） and "7 seven" and older group （49 years old and above）. The age， average menstrual cycle in the past 3 months， basic hormone levels including follicle stimulating hormone （FSH）， luteinizing hormone （LH）， estradiol （E2）， testosterone （T） and FSH/LH value， and anti-müllerian hormone （AMH） levels were collected and compared. ResultsA total of 1221 cases were included. The differences in FSH， LH， FSH/LH values， E2， T， AMH levels and average menstrual cycle among the groups were statistically significant （P＜0.05 or P＜0.01）. AMH peaked in the "3 seven" group. Compared to those in the "3 seven" group， the FSH/LH value in the "4 seven" group increased， while the LH， AMH and T levels decreased， and the menstrual cycle was shortened （P＜0.01）. The FSH/LH， LH， AMH， T and menstrual cycle in the "5 seven" group were consistent with the changing trend of those in the "4 seven" group， while the FSH and E2 levels in the "5 seven" group were significantly higher （P＜0.05 or P＜0.01）. Compared to those in the "5 seven" group， the FSH， LH and E2 levels of the "6 seven" group increased， and the AMH and T levels continued to decrease （P＜0.05 or P＜0.01）. Compared to those in the "6 seven" group， the FSH and LH levels of the "7 seven" and older group continued to increase， and the AMH and E2 levels decreased （P＜0.01）. ConclusionThe law of women reproductive aging in the "seven-year period" theory is basically consistent with the characteristics of basic sex hormone levels and anti-müllerian hormone levels in women of different ages. The reproductive capacity reaches its peak in the "three-seven-year period" and gradually moves towards reproductive aging in the "four-seven-year period".
