The optimal preemptive dose of gabapentin following gynecologic surgery.
10.4097/kjae.2009.56.3.309
- Author:
Hyo Seok KANG
1
;
Hye Jin PARK
;
Juyoun CHOI
;
So Jin PARK
;
Su kyeong LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, College of Medicine, Eulji University, Seoul, Korea. anesthjin@hanmail.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Fentanyl;
Gabapentin;
Post operative pain control
- MeSH:
Amines;
Analgesia, Patient-Controlled;
Animals;
Cyclohexanecarboxylic Acids;
Female;
Fentanyl;
gamma-Aminobutyric Acid;
Gynecologic Surgical Procedures;
Humans;
Laparotomy;
Nociceptive Pain
- From:Korean Journal of Anesthesiology
2009;56(3):309-312
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Gabapentin decreases acute nociceptive pain in animal and human studies when given before surgical incision. Various doses of gabapentin have been used (300-1,200 mg) to measure this preemptive effect. Here, we evaluated the optimal dose of gabapentin for reducing fentanyl consumption and the adverse effects of gabapentin following gynecologic surgery. METHODS: We recruited 100 patients who underwent laparotomy for gynecologic surgery. Patients were randomly divided into 4 groups and received a placebo (control), gabapentin 300 mg (G 300), gabapentin 600 mg (G 600), or gabapentin 1,200 mg (G 1200) 2 h before surgery. Postoperatively, patients received fentanyl via an intravenous patient controlled analgesia device. The cumulative fentanyl doses were recorded 2, 6, 12, 24 h, and 48 h postoperatively, and the sedation scale was recorded in the post anesthetic care unit (PACU). RESULTS: The postoperative fentanyl requirement was lower with gabapentin treatment, but there was no significant differences for the different doses. PACU sedation scores were not different in any group. CONCLUSIONS: Gabapentin has a preemptive effect in gynecologic surgery, but there were no additional fentanyl-sparing benefits at doses above 300 mg. Thus, 300 mg is an optimal dose for decreasing fentanyl consumption following gynecologic surgery.
