Role of Iron-lipid Disorder in Nonalcoholic Fatty Liver Disease and Research Progress of Traditional Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20240440
- VernacularTitle:铁-脂紊乱在非酒精性脂肪性肝病中的作用及中药干预研究进展
- Author:
Yanxu CHEN
1
;
Lei ZHANG
1
;
Zhisheng JIN
1
;
Qinyuan ZHANG
1
;
Xiaoxue JIANG
1
;
Changqing XU
1
;
Pengcheng DOU
1
;
Cong SUN
2
Author Information
1. Gansu University of Chinese Medicine， Lanzhou 730000， China
2. Shandong University of Traditional Chinese Medicine， Jinan 250000， China
- Publication Type:Journal Article
- Keywords:
nonalcoholic fatty liver disease （NAFLD）;
iron-lipid disorder;
signal pathway;
traditional Chinese medicine;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(18):281-290
- CountryChina
- Language:Chinese
-
Abstract:
Nonalcoholic fatty liver disease （NAFLD） is one of the most common complications of type 2 diabetes mellitus （T2DM）. Cell death caused by iron-lipid disorder is a new mode of regulating programmed cell death， which is characterized by lipid peroxidation induced by the accumulation of lipid reactive oxygen species and excessive accumulation of iron ions induced by iron metabolism disorders. Among them， iron homeostasis disorder and metabolic pathway disorder are the main causes of iron-lipid disorder， which play an important role in a variety of pathological processes related to cell death. Because the liver is an important organ for iron storage and lipid metabolism， iron-lipid disorder is an ideal target for liver disease， and inhibition of iron-lipid disorder may become a new strategy for the treatment of NAFLD. However， the pathogenic relationship and mechanism between NAFLD and iron-lipid disorder have not been fully elucidated. Based on the complex molecular regulation mechanism of iron-lipid disorder， by expounding the role of iron-lipid disorder in NAFLD and its related mechanism， this paper summarizes the research status of traditional Chinese medicine on the target treatment of NAFLD in recent years， so as to provide a new perspective and point out a new direction for the treatment of NAFLD in the future.
