Ginsenosides in Treatment of Lung Cancer： A Review
10.13422/j.cnki.syfjx.20241426
- VernacularTitle:人参皂苷类成分治疗肺癌的研究进展
- Author:
Anqi LYU
1
;
Yufeng SHI
1
;
Jia KE
2
Author Information
1. College of Traditional Chinese Medicine（TCM），Hubei University of Chinese Medicine， Wuhan 430060， China
2. Hubei Provincial Hospital of TCM/Hubei University of Chinese Medicine Affiliated Hospital/Hubei Academy of TCM， Wuhan 430074， China
- Publication Type:Journal Article
- Keywords:
ginsenosides;
pharmacological activity;
lung cancer;
traditional Chinese medicine;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(18):270-280
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is the leading cause of cancer-related death， characterized by high invasiveness， early metastasis and poor prognosis. It has the highest incidence and mortality rates among cancers in China. Currently， the treatment of lung cancer is still dominated by the classic therapies such as surgery， radiotherapy， chemotherapy and targeted therapy. However， the classic therapies are not suitable for all patients with lung cancer， so new treatment strategies and methods are needed to prevent and treat lung cancer. In recent years， Ginseng Radix et Rhizoma has attracted wide attention in the field of anti-lung cancer research， and traditional Chinese medicine has a substantial theoretical and practical foundation in treating lung cancer. Ginseng Radix et Rhizoma ， as a commonly used Chinese herbal medicine， has the functions of replenishing vital Qi， replenishing veins， strengthening the spleen and lung， and nourishing body and blood. The main active components of Ginseng Radix et Rhizoma ， known as ginsenosides， exhibit anti-cancer and anti-inflammatory activities. Therefore， the mechanism and pharmacological activity of ginsenosides in the intervention of lung cancer have been extensively studied by researchers worldwide. The results show that ginsenosides can effectively inhibit the proliferation， invasion， migration， epithelial-mesenchymal transition and angiogenesis of lung cancer cells. Additionally， they inhibit drug resistance， enhance chemotherapy sensitivity and efficacy， and promote apoptosis and autophagy of lung cancer cells. Ginsenosides also modulate the tumor microenvironment and regulate immunity， thereby delaying the occurrence and development of lung cancer. The rapid advancements in related research have outpaced previous literature review， creating challenges for scholars seeking the latest information. Based on this， this article summarizes recent findings on the mechanism and pharmacological activities of ginsenosides in lung cancer intervention， aiming to provide new insights for the development of molecular biology， drug treatment research and clinical new drug research in lung cancer. It also provides the reference for further mechanism research.
