Traditional Chinese Medicine Regulates Oxidative Stress-related Signaling Pathways to Prevent and Treat Bronchial Asthma： A Review
10.13422/j.cnki.syfjx.20231818
- VernacularTitle:中医药调控氧化应激相关信号通路防治支气管哮喘研究进展
- Author:
Xuyang ZHENG
1
;
Zhenhui SHU
1
;
Yi LI
2
;
Ziyue QU
3
;
Weilin LI
1
;
Kexin MA
1
;
Junsheng SHA
1
;
Limin ZHAO
2
Author Information
1. The First Clinical Medical School， Henan University of Chinese Medicine， Zhengzhou 450000， China
2. People's Hospital of Zhengzhou University， Zhengzhou 450003， China
3. People's Hospital of Henan University， Zhengzhou 450003， China
- Publication Type:Journal Article
- Keywords:
bronchial asthma;
oxidative stress;
traditional Chinese medicine;
reactive oxygen species （ROS）;
mitogen-activated protein kinase（MAPK）;
nuclear transcription factors（NF）-κB;
nuclear factor-erythroid 2-related factor 2（NrF2）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(18):260-269
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma （asthma for short） is a common clinical respiratory disease mainly characterized by chronic airway inflammation， with complicated pathogenesis and a long treatment cycle. It is lingering and difficult to be cured， and lack specific drugs. Oxidative stress is a new focus in the research on the pathogenesis of asthma and a potential key target for the treatment. Under physiological conditions， the oxidative and antioxidative systems in the body are in a dynamic balance， and the two antagonize each other to maintain normal life activities. In the case of asthma attack， oxidation products such as reactive oxygen species （ROS）， malondialdehyde （MDA）， and nitric oxide （NO） are produced excessively， while the content of antioxidants such as superoxide dismutase （SOD）， catalase （CAT）， and glutathione （GSH） is reduced. As a result， the oxidation exceeds the removal of oxidation products， which aggravates oxidative stress. In addition， the overproduction of ROS activates oxidative stress-related signaling pathways to produce pro-inflammatory factors， exacerbating inflammation， which leads to lung and airway tissue damage. In recent years， traditional Chinese medicine has garnering increasing attention because of the unique advantages in the treatment of asthma， especially in regulating redox balance， alleviating oxidative stress in asthma patients， and reducing inflammation. On the one hand， by inhibiting the mitogen-activated protein kinase （MAPK） and transcription factor （NF）-κB signaling pathways， traditional Chinese medicine can reduce the content of oxidation products and pro-inflammatory factors from the source. On the other hand， by activating the nuclear factor-erythroid 2-related factor 2 （NrF2） signaling pathway， traditional Chinese medicine can elevate the levels of antioxidant enzymes and enhance the antioxidant system to neutralize the excessive accumulation of oxidation products. Therefore， the adjustment of redox balance state by traditional Chinese medicine may be a new means and a new direction for the prevention and treatment of asthma in the future. This paper summarizes the oxidative stress-related pathways in the pathogenesis of asthma and reviews the latest research progress in the regulation of oxidative stress-related pathways by Chinese medicine extracts and prescriptions in the treatment of asthma， with a view to providing a fuller， more solid， and more scientific theoretical basis for the clinical and basic research on the prevention and treatment of asthma by traditional Chinese medicine.
