Niuhuang Qingxin Pills and Active Ingredients in Prevention and Treatment of Stroke： A Review
10.13422/j.cnki.syfjx.20240905
- VernacularTitle:牛黄清心丸及其活性成分防治脑中风的研究进展
- Author:
Miling ZHANG
1
;
Liangying BAO
1
;
Yujie DAI
1
;
Shuaishuai GONG
1
;
Junping KOU
1
Author Information
1. Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research，Department of Pharmacology of Chinese Materia Medica，School of Traditional Chinese Pharmacy，China Pharmaceutical University，Nanjing 211198，China
- Publication Type:Journal Article
- Keywords:
Niuhuang Qingxin pills;
stroke;
cerebral ischemia;
intracerebral hemorrhage;
active ingredients
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(18):251-259
- CountryChina
- Language:Chinese
-
Abstract:
Stroke is a neurological disease characterized by cerebral ischemia or hemorrhagic injury， leading to death and disability worldwide. At present， there is still a lack of neuroprotective drugs for the treatment of stroke. Niuhuang Qingxin pills are Chinese patent medicine recommended by guidelines and expert consensus for preventing and treating stroke. Studies have shown that Niuhuang Qingxin pills have sedative， anticonvulsant， antipyretic， and other pharmacological effects. Moreover， the main components， such as flavonoids， phenolic acids， and saponins， also exhibit strong pharmacological activities which can improve stroke-induced nerve damage. Studies have confirmed that representative ingredients such as baicalin and ginsenosides can interfere with multiple pathological events， including blood-brain barrier destruction， oxidative stress， inflammatory response， apoptosis， and autophagy， and the mechanisms of the essential ingredients are related to the action on important targets such as Kelch-like ECH-associated protein 1 （Keap1）， matrix metalloproteinase-9 （MMP-9）， and high-mobility group box 1 （HMGB1）， and involvement in the regulation of Toll-like receptor 4 （TLR4）/nuclear factor-κB （NF-κB）， nuclear factor E2-related factor 2 （Nrf2）/heme oxygenase-1 （HO-1）， and phosphoinositide 3-kinase （PI3K）/protein kinase B （Akt） signaling pathways. This article summarized the research status of Niuhuang Qingxin pills and the experimental pharmacological progress of common ingredients in the prevention and treatment of stroke to provide clues for further research into Niuhuang Qingxin pills and the development of active ingredients of traditional Chinese medicines.
