Research Progress and Quality Marker Prediction of Famous Classical Formula Baihe Dihuangtang
10.13422/j.cnki.syfjx.20240867
- VernacularTitle:经典名方百合地黄汤的研究进展及质量标志物预测
- Author:
Yan LIU
1
;
Jiameng LIU
1
;
Dan LI
2
;
Bo SUN
3
;
Jingfan YANG
4
;
Yu FU
4
;
Shengjun MA
5
;
Guangwei ZHU
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
2. China Shineway Pharmaceutical Group Co. Ltd.，Shijiazhuang 051430，China
3. Institute of Medicinal Biotechnology，Chinese Academy of Medical Sciences&Peking Union Medical College，Beijing 100050，China
4. School of Pharmacy，Henan University of Chinese Medicine，Zhengzhou 450046，China
5. School of Food Sciences and Pharmacy，Xinjiang Agricultural University， Urumqi 830052，China
- Publication Type:Review
- Keywords:
Baihe Dihuangtang;
historical evolution;
clinical application;
pharmacological effect;
quality marker（Q-Marker）;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(18):235-242
- CountryChina
- Language:Chinese
-
Abstract:
Baihe Dihuangtang is a famous classical formula that has been respected by physicians in the past and is still used today. It was first recorded in ZHANG Zhongjing's Synopsis of the Golden Chamber， and is composed of Lilii Bulbus and Rehmanniae Radix juice. This paper systematically reviewed the research progress of historical evolution， pharmacological activities and clinical applications of Baihe Dihuangtang in recent years， and found that there was no major changes in the composition， decoction method and indications of this formula since the Han dynasty. According to the herbal textual research， the fleshy scaly leaves of Lilium brownii var. viridulum should be selected for Lilii Bulbus in this formula， and the tuberous roots of Rehmannia glutinosa were selected for Rehmanniae Radix. According to the dosage conversion of ancient and modern times， the dosage is 245 g of fresh Lilii Bulbus and 400 g of fresh Rehmanniae Radix， and the ratio of their juice is 1∶1. Its efficacy is to nourish Yin and clear heat， and to tonify the heart and lungs， which is used to treat the heart and lung Yin deficiency syndrome of lily disease. Modern pharmacological studies have shown that the research on the pharmacological effects of Baihe Dihuangtang mainly focuses on anti-depressant， anti-anxiety， improving insomnia and regulating metabolism， and it is mostly used clinically for neurological disorders such as depression， anxiety and insomnia. The quality marker（Q-Marker） of Baihe Dihuangtang were predicted according to the principles of ingredient specificity， component validity， component measurability， formula compatibility， and quality transmissibility and traceability， and it was determined that catalpol， rhmannioside D， regaloside A， regaloside B， regaloside C， and acteoside could be selected as potential Q-Markers of Baihe Dihuangtang， which could provide scientific reference for the establishment of the quality control system and the development of compound preparation of this famous classical formula.
