Study on the correlation between positive antinuclear antibody and intervention therapy and assisted reproductive outcome of repeated implantation failure
10.19405/j.cnki.issn1000-1492.2024.06.004
- Author:
Hui Xiao
1
;
Wen Zhu
2
,
3
;
Fan Yang
2
,
3
;
Yuge Chen
2
,
3
;
Guanxiong Wang
2
,
3
;
Huan Wu
2
,
3
Author Information
1. Dept of Rheumatology and Immunology , The First Afiliated Hospital of Anhui Medical University, Hefei 230032
2. Dept of Obstetrics and Gynecology , The First Afiliated Hospital of Anhui Medical University, Hefei 230032
3. NHC Key Laboratory of Abnormal Gametes and Reproductive Tract , Anhui Medical University , Hefei 230032
- Publication Type:Journal Article
- Keywords:
antinuclear antibody;
infertility;
repeated implantation failure;
clinical outcome
- From:
Acta Universitatis Medicinalis Anhui
2024;59(6):947-951
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the impact of positive antinuclear antibody (ANA) and subsequent intervention therapy on the assisted reproductive technology outcomes among the patients experiencing recurrent implantation failure (RIF) .
Methods :A retrospective study was conducted on 344 RIF patients . Based on ANA test results , the patients were divided into ANA⁃positive group (294 cases) and negative control group (50 cases) . The ANA⁃positive group was further divided into a low titer group (214 cases) and a high titer group (80 cases) . Comparative statistical analyses such as the Wilcoxon rank⁃sum test , Mann⁃Whitney U test , Kruskal - Wallis test and chi⁃square test , etc . were employed to evaluate differences in general clinical data , embryo⁃related parameters , and pregnancy outcomes between the positive and negative groups . The impact of ANA on the assisted reproductive outcomes of patients with recurrent implantation failure was analyzed , and the outcomes of ANA⁃positive patients after intervention therapy were also analyzed .
Results :Notably , the clinical pregnancy rates of patients in the ANA⁃positive low titer group and high titer group were significantly lower than those in the negative control group ( P < 0. 001) . Similarly , the rates of fertilization and cleavage of oocytes in ANA⁃positive patients were also significantly lower than those in the negative control group (P < 0. 05) . For patients who did not achieve pregnancy after embryo transfer due to ANA positivity , immunomodulatory therapy significantly improved both the clinical pregnancy rate and cumulative clinical pregnancy rate (P < 0. 05) .
Conclusion :Compared with the negative control group , the clinical pregnancy rates decrease in both ANA⁃positive low titer subgroup and high titer subgroup . However , clinical intervention therapy enhances the single⁃cycle clinical pregnancy and cumulative pregnancy rates among ANApositive patients , indicating that ANA positivity is an important factor in RIF . Immunomodulatory therapy is an effective measure to improve recurrent implantation failure among ANA⁃positive patients .
- Full text:2024081420322491471抗核抗体阳性及干预治疗与反...失败辅助生殖结局相关性研究_肖会.pdf
