A Case of Secondary Antiphospholipid Antibody Syndrome with Thyroid Cancer.
- Author:
Seung Hun KANG
1
;
Sung Jae CHOI
;
Young Ho LEE
;
Jong Dae JI
;
Gwan Gyu SONG
Author Information
- Publication Type:Case Report
- Keywords: Antiphospholipid antibody syndrome; Malignancy; Thyroid cancer
- MeSH: Antibodies, Anticardiolipin; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Autoimmune Diseases; Blood Coagulation Factors; Communicable Diseases; Hematologic Neoplasms; Hemophilia A; Humans; Korea; Lupus Coagulation Inhibitor; Mass Screening; Pregnancy Complications; Thromboplastin; Thrombosis; Thyroid Gland; Thyroid Neoplasms
- From:Journal of Rheumatic Diseases 2011;18(1):46-49
- CountryRepublic of Korea
- Language:Korean
- Abstract: Antiphospholipid antibody syndrome (APS) is defined as the presence of lupus anticoagulant antibody or anticardiolipin antibody with vascular thrombosis or pregnancy complications. APS can be associated with autoimmune disease or infectious disease. APS has also been reported in conjunction with variety of solid and hematologic malignancies. There were some reports on APS which were accompanied by hematologic malignancy, but there was no report with solid malignancy in Korea. We experienced one case of secondary APS, which was diagnosed during pre-operative evaluation of thyroid cancer. This patient had prolonged aPTT (activate partial thromboplastin time) and decreased coagulation factors which were regarded as hemophilia at first. Although the precise mechanism of the relationship between APS and cancer has not been proven thoroughly, APS can be accompanied by various malignancies. So proper screening and early detection of malignancies in APS patients are recommended.
