The correlation research of UGRP1 with latent autoimmune diabetes in adults
10.19405/j.cnki.issn1000-1492.2023.05.027
- Author:
Dan Wang
1
;
Shanshan Ma
1
;
Tian Xu
1
;
Chunlin Zuo
1
Author Information
1. Dept ofEndocrinology, The First Afiliated Hospital of Anhui Medical University,Hefei 230022
- Publication Type:Journal Article
- Keywords:
latent autoimmune diabetes in adult;
uteroglobin⁃related protein 1;
type 2 diabetes mellitus
- From:
Acta Universitatis Medicinalis Anhui
2023;58(5):863-867
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the correlation of uteroglobulin⁃related protein 1 (UGRP1) with latent autoimmune diabetes in adults (LADA) .
Methods:124 participants were selected , including 45 LADA patients as LADA group ,41 type 2 diabetes mellitus (T2DM) patients as T2DM group and 38 healthy people without diabetes as control group. General information , diabetes related indicators and serum UGRP1 levels were compared among the three groups. Spearman correlation was used to analyze the relationship between serum UGRP1 and diabetes related indicators. Binary logistic regression was used to analyze whether UGRP1 could be an independent risk factor for LADA. The diagnostic value of UGRP1 in LADA was discussed by ROC curve analysis.
Results:There were significant differences in BMI , systolicpressure , diastolicpressure , fasting blood glucose , 2h postprandial blood glucose , fasting C ⁃peptide , 2h postprandial C ⁃peptide , HbA1 c , diabetes antibodies( GADAb , IA⁃2 , ZnT8) among the three groups (P < 0. 05) . The level of serum UGRP1 in LADA group was significantly higher than that in control group and T2DM group (P < 0. 05) . Spearman correlation analysis showed that the serum UGRP1 level of diabetes patients was related to fasting C ⁃peptide , 2h postprandial C ⁃peptide , GADAb , the number of positive diabetes antibodies. Binary Logistic regression analysis showed that serum UGRP1 level was an independent risk factor for LADA. ROC curve analysis results suggested that UGRP1 could be used as a better assistant indicator for the diagnosis of LADA.
Conclusion:UGRP1 may be involved in the pathogenesis of LADA.
- Full text:2024081322115352617UGRP1与成人隐匿性自身免疫性糖尿病的相关性_王丹.pdf
