A Case of Klinefelter's Syndrome Associated with Rheumatoid Arthritis.
- Author:
Sang Il MO
1
;
Hyeok Gyu LEE
;
A Ra CHO
;
Hye Kyoung CHUNG
;
Ki Won KIM
;
Han Min LEE
;
Byong Il KANG
;
Gyu Bong KO
;
Se Whan LEE
;
Seong Su NAH
Author Information
- Publication Type:Case Report
- Keywords: Klinefelter's syndrome; Rheumatoid arthritis; X chromosome
- MeSH: Aluminum Hydroxide; Arthritis, Rheumatoid; Autoimmune Diseases; Carbonates; Hand; Humans; Hypogonadism; Karyotype; Klinefelter Syndrome; Lupus Erythematosus, Systemic; Male; X Chromosome
- From:Journal of Rheumatic Diseases 2011;18(1):60-63
- CountryRepublic of Korea
- Language:Korean
- Abstract: Klinefelter's syndrome (KFS) is a gonosomal aberration disease that occurs in males, and is characterized by 47, XXY karyotype, hypogonadism and a lack of secondary sexual characteristics. A potential link between this hormonally deficient syndrome and autoimmune disease, particularly systemic lupus erythematosus (SLE), has been reported. On the other hand, KFS is rarely reported to be accompanied by rheumatoid arthritis (RA), and there are no Korean cases reported. We report the first Korean case of a KFS patient with sero-positive RA and discuss the role of the pathogenesis of RA with KFS.
