Rapid health technology assessment of the efficacy，safety and cost-effectiveness of vericiguat in the treatment of heart failure
- VernacularTitle:维立西呱治疗心力衰竭有效性、安全性及经济性的快速卫生技术评估
- Author:
Yijun KE
1
;
Wei WANG
2
;
Can HUANG
1
;
Yong JIN
3
;
Lamei QI
1
Author Information
1. Dept. of Pharmaceutical Administration，Anqing Municipal Hospital，Anhui Anqing 246000，China
2. Dept. of Gastroenterology，Anqing Municipal Hospital，Anhui Anqing 246000，China
3. School Hospital of Anhui Medical University，Hefei 230000，China
- Publication Type:Journal Article
- Keywords:
vericiguat;
heart failure;
efficacy;
safety
- From:
China Pharmacy
2024;35(15):1818-1824
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the efficacy， safety and cost-effectiveness of vericiguat in the treatment of heart failure （HF） by rapid health technology evaluation method， and provide reference for the selection and decision-making of clinical treatment plans. METHODS Chinese and foreign databases such as CNKI， PubMed and related health technology evaluation websites were searched by computer. Relevant researchers independently screened literature， extracted data， and comprehensively analyzed the results of the included literature based on literature quality evaluation. RESULTS A total of 17 pieces of literature were included， involving 12 systematic reviews/meta-analyses and 5 pharmacoeconomic studies. The effectiveness analysis showed： for HF patients， compared with placebo， vericiguat （10 mg/d） significantly improved the EuroQol five dimensions questionnaire （EQ-5D） index and decreased the rate of hospitalization due to HF （P＜0.05）. For heart failure with reduced ejection fraction （HFrEF） patients， vericiguat reduced the incidence of hospitalization due to HF compared with sodium-glucose cotransporter 2 inhibitor （SGLT2i）（P＜0.05）； compared with angiotensin-converting enzyme inhibitor， vericiguat significantly reduced the occurrence risk of composite endpoints of cardiovascular death or hospitalization due to HF（P＜0.05）. For HFrEF patients with chronic kidney disease， vericiguat had a tendency to reduce the occurrence risk of composite endpoints of cardiovascular death or hospitalization due to HF compared with neurohormone inhibitors. Safety analysis showed： vericiguat did not increase drug-related adverse reactions compared to placebo （P＞0.05）. Economic analysis showed： domestic studies indicated that vericiguat had a higher incremental cost-effectiveness ratio. CONCLUSIONS Vericiguat has good safety and efficacy in the treatment of HF but does not possess an economic advantage in the Chinese population.
