Relationship between 24 h ambulatory blood pressure circadian rhythm and renal involvement in lupus nephritis
10.19405/j.cnki.issn1000-1492.2022.10.027
- Author:
Bomiao Ju
1
;
Pei Wang
1
;
Jing Wang
1
;
Xiaohong Lv
1
;
Nan Hu
1
;
Jing Luo
1
;
Lan He
1
Author Information
1. Dept of Rheumatology and Immunology, The First Affiliated Hospital of Xi an Jiaotong University,Xi an 710061
- Publication Type:Journal Article
- Keywords:
systemic lupus erythematosus;
lupus nephritis;
blood pressure c ircadian rhythm;
renal involvement
- From:
Acta Universitatis Medicinalis Anhui
2022;57(10):1661-1665
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the relationship between the 24 h ambulatory blood pressure c ircadian rhythm abnormalities and kidney damage in the patients of lupus nephritis (LN) .
Methods :A total of 103 patients with LN patients were enrolled retrospectively. All patients were accepted 24 h ambulatory blood pressure monitoring (ABPM) . The patients were divided into 2 groups according to the 24 h ambulatory blood pressure c ircadian rhythm, including nocturnal blood pressure meaning average declining during the day ( > 10% ) and non⁃dipper type blood pressure group ( < 10% ) . The kidney damage index of LN patients with or without hypertension or nocturnal blood pressure and non⁃dipper type blood pressure was analyzed. The influencing factors of the circadian rhythm of LN blood pressure were analyzed by binary Logistic regression.
Results :Among the 103 LN patients, 66 patients were hypertension, 37 patients were none hypertension. Fifty⁃nine patients were non⁃dipper type blood pressure in LN with hypertension group, and 30 patients were non⁃dipper type blood pressure in LN without hypertension. There was no significant difference in the frequency of non⁃dipper type blood pressure between the two groups (81. 1% vs 89. 4% , χ2 = 1. 395, P = 0. 238) . Compared with hypertension group, the levels of serum creatinine (Z = 2. 911, P = 0. 004), urea ( Z = 3. 348, P = 0. 001) and uric acid levels ( t = 2. 017, P = 0. 047 ) were significantly higher than those of LN without hypertension patients, whereas the levels of glomerular filtration rate (eGFR) (Z = 4. 846, P < 0. 001) were significantly lower than those of LN without hypertension patients. In the group of LN with hypertension, the levels of uric acid (Z = 2. 893, P = 0. 004) were significantly higher than those of nocturnal blood pressure subgroup patients compared with no dipper type blood pressure subgroup patients, and the levels of eGFR (Z = 2. 017, P = 0. 0440) were significantly lower. Nevertheless, in the group of LN without hypertension, the kidney damage index had no significant difference between the two subgroups. Univariate and multivariate analysis showed that uric acid was associated with an abnormal rhythm of LN combined with hypertension.
Conclusion :Abnormal blood pressure rhythms are common in LN patients with or without hypertension. Renal damage significantly increases in the non⁃dipper group of LN compared with hypertension patients.
- Full text:2024081217170830083狼疮性肾炎患者24_h动态...压昼夜节律与肾脏损害的关系_俱博苗.pdf
