Research progress on differential diagnosis of thalassemia trait and iron deficiency anemia by blood erythrocyte parameters.
10.3760/cma.j.cn112150-20230601-00427
- Author:
Li Xia CUI
1
;
Ling JI
2
Author Information
1. Department of Clinical Diagnostic Laboratory, Shantou University, Shantou 515100, China Medical Laboratory,Peking University Shenzhen Hospital, Shenzhen 518000, China.
2. Medical Laboratory,Peking University Shenzhen Hospital, Shenzhen 518000, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Anemia, Iron-Deficiency/diagnosis*;
Diagnosis, Differential;
beta-Thalassemia/diagnosis*;
Erythrocytes;
Thalassemia/genetics*;
Iron
- From:
Chinese Journal of Preventive Medicine
2024;58(1):122-127
- CountryChina
- Language:Chinese
-
Abstract:
Thalassemia trait is an autosomal recessive genetic disease, which is a hemolytic anemia caused by disturbance of erythrocyte hemoglobin production caused by gene mutation or deletion. Iron deficiency anemia is caused by a lack of iron in the body due to an imbalance between the demand and supply of iron. The laboratory manifestations of both are microcytic hypochromic anemia, but the treatment schemes are completely different, and it is difficult to distinguish them from the results of blood count. Erythrocyte parameters can be used to establish a formula or model to differentiate them, which can achieve the purpose of early screening, early diagnosis and early treatment,preventing the occurrence of severe anemia and providing a scientific basis for the thalassemia and iron deficiency anemia prevention. This article will review the research progress of using erythrocyte parameters to distinguish thalassemia trait with iron deficiency anemia.
