The similar characteristics of IgG4-related disease and allergic diseases.
10.3760/cma.j.cn112150-20230712-00535
- Author:
Sai Nan BIAN
1
;
Kai GUAN
1
Author Information
1. Allergy Department, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Disease, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Immunoglobulin G4-Related Disease;
Asthma;
Rhinitis, Allergic;
Cytokines;
Inflammation
- From:
Chinese Journal of Preventive Medicine
2023;57(12):1936-1941
- CountryChina
- Language:Chinese
-
Abstract:
IgG4-related disease (IgG4-RD) is a chronic inflammation with fibrosis. About 30% to 40% of patients with IgG4-RD are complicated with atopic manifestations as allergic rhinitis and asthma, usually with elevated serum total immunoglobulin E and peripheral blood eosinophils, which are also of some value for predicting disease activity and relapse. Similar to allergic diseases, activation of type 2 inflammation is also observed in the pathogenesis of IgG4-RD, and eosinophils, basophils, mast cells, thymic stromal lymphopoietin, IL-33, IL-4, IL-5, and IL-13 all participate in the pathogenesis of IgG4-RD. Studies of susceptible genes showed that IgG4-RD and allergic disease shared the same susceptible genes. Monoclonal antibodies targeting type 2 inflammation pathway may become a novel choice for IgG4-RD treatment.
