Research progress on the role of glucose in regulating immune homeostasis.
10.3760/cma.j.cn112150-20221205-01178
- Author:
Hui Yi CHEN
1
;
Hai Li WU
1
;
Hui WANG
1
;
Xiao Guang LI
1
Author Information
1. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Glucose/metabolism*;
Homeostasis/physiology*
- From:
Chinese Journal of Preventive Medicine
2023;57(11):1882-1887
- CountryChina
- Language:Chinese
-
Abstract:
Glucose is the central nutrient for energy metabolism and life support in the human body. As the main energy substance of the body, glucose is essential for the normal function of immune cells and their proliferation; when glucose homeostasis is disrupted in the body, it may lead to impaired immune system function and pathological conditions. Exploring the relationship between glucose metabolism and immune regulation can help establish the gene regulatory network and figure out potential pathogenic mechanisms under physiological and pathological conditions. This article reviews the current scientific research progress on glucose metabolism and immunity, mainly focusing on the physiological regulatory functions of glucose in maintaining the homeostasis of innate and acquired immunity; and summarizes the research progress on the effects and mechanisms of glucose on tumor immunity and its related therapies under pathological conditions, taking tumors as an example.
