Genome sequence analysis of two SARS-CoV-2 virus infections in Inner Mongolia, 2022.
10.3760/cma.j.cn112150-20230104-00009
- Author:
Guo Qing YANG
1
;
Chao MIN
2
;
Jian SONG
2
;
Xiao Feng JIANG
2
;
Hua YUE
2
;
Xiao Wei NAN
2
;
Zhen YAN
2
;
Ai Tao LU
3
;
Yan HAI
3
;
Zhan Song ZHU
4
Author Information
1. Public Health School of Inner Mongolia Medical University, Hohhot 010000, China.
2. Inner Mongolia Autonomous Region Comprehensive Center for Disease Control and Prevention Biosafety Level III Laboratory, Hohhot 010080, China.
3. Public Health School of Inner Mongolia Medical University, Hohhot 010000, China Inner Mongolia Autonomous Region Comprehensive Center for Disease Control and Prevention Biosafety Level III Laboratory, Hohhot 010080, China.
4. Department of Laboratory, Center for Disease Control and Prevention, Hulun Buir 021000, China.
- Publication Type:Journal Article
- MeSH:
Humans;
COVID-19;
SARS-CoV-2/genetics*;
Phylogeny;
Genome, Viral;
Nucleotides;
Sequence Analysis
- From:
Chinese Journal of Preventive Medicine
2023;57(10):1630-1634
- CountryChina
- Language:Chinese
-
Abstract:
The target gene sequences of the novel coronaviruses obtained by sequencing were compared with the reference sequences to analyze the genetic variation of the two cases of the novel coronaviruses from Inner Mongolia Autonomous Region in 2022 and to explore the sources of infection. The results showed that the two sequences belonged to different evolutionary branches, Delta (AY.122) and Omicron (BA.1.1), respectively. hCoV-19/Inner Mongolia/IVDC-591/2022 had 48 single nucleotide polymorphisms on the genome sequences, sharing 40 nucleotide mutation sites with a Mongolian strain; hCoV-19/Inner Mongolia/IVDC-592/2022 genome shared 57 nucleotide mutation sites with a UK strain, and the nucleotide mutation site identity was 100% (57/57). Phylogenetic analysis showed that the target gene sequences were not directly related to domestic novel coronavirus sequences during the same period, but were related to isolates from Europe and Mongolia.
