Molecular diagnostic strategies and management of dust mite allergy.
10.3760/cma.j.cn112150-20231129-00384
- Author:
Hui GAN
1
;
Li Ting WU
1
;
Bao Qing SUN
1
Author Information
1. Department of Clinical Laboratory of the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou 510120, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Dust;
Dust Mite Allergy;
Pathology, Molecular;
Antigens, Dermatophagoides;
Allergens;
Hypersensitivity/therapy*;
Pyroglyphidae
- From:
Chinese Journal of Preventive Medicine
2024;58(1):148-154
- CountryChina
- Language:Chinese
-
Abstract:
Dust mites are one of the most important allergens, widely distributed around the world, especially in household environments. Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis are the most common species of dust mites. There are more than 35 known sensitization components of dust mites, among which Der p 1, Der p 2 and Der p 23 are the major components. Clinically, allergen skin test and serum specific immunoglobulin E (sIgE) detection are widely used in the preliminary diagnosis of dust mite allergy. However, these methods cannot accurately identify specific dust mite sensitization components. Considering that there are significant differences in the allergenic components of dust mites in different regions and populations, component-resolved diagnosis of dust mite is particularly important in accurately determining the allergenic components. This is not only of guiding significance for allergen avoidance, but also important for determining the immunotherapy regimen for dust mites. In order to strengthen the understanding of the molecular diagnosis of dust mites and promote the integration of allergy science in China with the international standards, this article interprets the "Allergy Molecular Allergology User's Guide 2.0" published recently by the European Academy of Allergy and Clinical Immunology.
