Research progress on exosomes and exosomal microRNAs in the occurrence and development of diabetic peripheral neuropathy

VernacularTitle:外泌体与外泌体microRNAs在糖尿病周围神经病变发生发展中的研究进展
Author: Yang SHU ¹ ; Weidong LI ; Qiongying HU ; Daqian XIONG
Author Information

1. 成都中医药大学附属医院检验科，成都　610072
Keywords: Diabetic peripheral neuropathy; Exosomes; Exosomal-miRNAs; High sugar condition
From: Chinese Journal of Preventive Medicine 2024;58(1):141-147
CountryChina
Language:Chinese
Abstract: Diabetic peripheral neuropathy (DPN) is one of the chronic complications of diabetic neuropathy, and also the main cause of chronic wounds and disability. Exosomes and exosomal-microRNAs (miRNAs) are closely related to DPN and participate in the signal transduction and protein expression of the peripheral nervous system by mediating intercellular communication. However, the specific role and mechanism of EVs and exosomal-miRNAs in the occurrence and development of DPN in high-glucose environments are not fully understood. This article reviews the promotion of EVs and exosomal-miRNAs in the occurrence and development of DPN in inhibiting axon growth, promoting inflammatory response, and inducing vascular injury in a high glucose environment.