Periodic dynamic observation and analysis of cellular and humoral immunity indexes of adults infected with Omicron BA.1.
10.3760/cma.j.cn112150-20230526-00410
- Author:
Meng Xue GAO
1
;
Yue LEI
2
;
Li Ru GUO
2
;
Jiang Wen QU
3
;
He Fei WANG
3
;
Xiao Man LIU
1
;
Rui LI
1
;
Mei KONG
2
;
Zhi Chao ZHUANG
2
;
Zhao Lin TAN
2
;
Xiao Yan LI
4
;
Ying ZHANG
5
Author Information
1. School of Public Health, Tianjin Medical University, Tianjin 300070, China Institute of Microbiology, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China.
2. Institute of Microbiology, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China Tianjin Key Laboratory of Pathogenic Microorganisms for Infectious Diseases, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China.
3. Institute of immunization, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China.
4. School of Public Health, Tianjin Medical University, Tianjin 300070, China Institute of Microbiology, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China Tianjin Key Laboratory of Pathogenic Microorganisms for Infectious Diseases, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China.
5. Department of Director, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Humans;
Immunity, Humoral;
Coinfection;
Interleukin-4;
Interleukin-5;
Immunoglobulin G;
Interferon-gamma
- From:
Chinese Journal of Preventive Medicine
2023;57(12):2117-2121
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the immunological characteristics and antibody changes of patients infected with the Omicron BA.1 and evaluate the possibility of secondary infection. Methods: A total of 104 patients infected with Omicron BA.1 in the Jinnan District of Tianjin from January 8 to February 2, 2022, were included in the study. The control group and case group were matched 1∶1 based on age, sex and vaccination status. Serum was collected from the case group and control group at 3, 6 and 9 months after infection. The serum levels of interleukin4 (IL-4), IL-5 and interferon-gamma (IFN-γ), as well as the positive rates of IgG, IgG1 and IgG2, were detected by ELISA. Results: The highest concentration of IFN-γ in the case group at 6 months after infection was 145.4 pg/ml, followed by a decrease in concentration. The concentrations of IL-4 and IL-5 began to decrease at 6 months after infection (all P<0.001). There was no significant difference in the IgG2 positive rate between the case group and the control group at 6 months after BA.1 infection. However, at 9 months, there was a significant decrease compared to the control group (P=0.003). The ratio of IFN-γ/IL4 at 3 months after infection in the case group was lower than that in the control group (P<0.001). There was no significant difference in the ratio between the case group and the control group at 9 months after infection. Conclusion: The cellular immune function has been impaired at 3 months after infection with BA.1, and the specific cellular immune and humoral immune functions decrease significantly after 6 months, and the risk of secondary infection increases.
