Advancements in the study of allergen-specific Th2 cell surface markers.
10.3760/cma.j.cn112150-20230819-00107
- Author:
Yue Hua MEN
1
;
Peng Hai SUN
2
;
Wen Hui WANG
1
;
Ming CHU
2
Author Information
1. Dermatology Department of Peking University Third Hospital,Beijing 100191,China.
2. Department of Immunology, Peking University Health Science Center,Beijing 100191,China.
- Publication Type:Journal Article
- MeSH:
Humans;
Allergens;
Th2 Cells
- From:
Chinese Journal of Preventive Medicine
2023;57(12):1949-1956
- CountryChina
- Language:Chinese
-
Abstract:
Allergen-specific Th2 cells refer to a subset of Th2 cells that undergo substantial expansion following allergen stimulation. They play a crucial role in allergic diseases, and an increasing amount of research has revealed a close relationship between surface molecules on allergen-specific Th2 cells and allergic diseases. In comparison to other CD4+T cells or Th2 cells, allergen-specific Th2 cells exhibit low expression of CD27 but high expression of CD154, CD69, CRTH2, CD161, ST2, hPGDs, CD49d, and COX-2. They can be used for the identification of allergen-specific Th2 cells and serve as potential targets for the prevention and treatment of specific diseases. They hold significant value in preventing the onset and exacerbation of allergic diseases.
