Research progress on eosinophils in lung cancer.
10.3760/cma.j.cn112150-20230421-00312
- Author:
Ya Qin WEI
1
;
Li Hua LYU
2
;
Ming LI
2
Author Information
1. School of Laboratory Medicine, Bengbu Medical College, Bengbu 233030, China Department of Laboratory Medicine, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230032, China.
2. Department of Laboratory Medicine, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230032, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Eosinophils/pathology*;
Lung Neoplasms;
Cytokines;
Hypersensitivity/pathology*;
Asthma/pathology*;
Tumor Microenvironment
- From:
Chinese Journal of Preventive Medicine
2023;57(11):1895-1900
- CountryChina
- Language:Chinese
-
Abstract:
Eosinophils are important immune cells that contain eosinophilic particles and play a key role in allergic diseases such as asthma and helminth infections. An increasing number of studies have confirmed that eosinophils infiltrate a variety of tumor tissues, which can synthesize and secrete a large number of bioactive substances under certain circumstances, such as cytotoxic cationic proteins, cytokines, growth factors, chemokines, enzymes and so on, which may affect angiogenesis and matrix remodeling or change the tumor microenvironment, thereby affecting tumor progression. This review focused on the role of eosinophils in lung cancer and provided an outlook on the issues in clinical and basic research.
