A preliminary prediction model of depression based on whole blood cell count by machine learning method.
10.3760/cma.j.cn112150-20221202-01169
- Author:
Jing YAN
1
;
Xin Yuan LI
2
;
Yu Lan GENG
2
;
Yu Fang LIANG
1
;
Chao CHEN
3
;
Ze Wen HAN
3
;
Rui ZHOU
1
Author Information
1. Department of Laboratory Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
2. Department of Laboratory Medicine, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China.
3. Beijing Jinfeng Yitong Technology Co., Ltd, Beijing 100020, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Depression;
Bayes Theorem;
Machine Learning;
Support Vector Machine;
Blood Cell Count
- From:
Chinese Journal of Preventive Medicine
2023;57(11):1862-1868
- CountryChina
- Language:Chinese
-
Abstract:
This study used machine learning techniques combined with routine blood cell analysis parameters to build preliminary prediction models, helping differentiate patients with depression from healthy controls, or patients with anxiety. A multicenter study was performed by collecting blood cell analysis data of Beijing Chaoyang Hospital and the First Hospital of Hebei Medical University from 2020 to 2021. Machine learning techniques, including support vector machine, decision tree, naïve Bayes, random forest and multi-layer perceptron were explored to establish a prediction model of depression. The results showed that based on the blood cell analysis results of healthy controls and depression group, the accuracy of prediction model reached as high as 0.99, F1 was 0.975. Receiver operating characteristic curve area and average accuracy were 0.985 and 0.967, respectively. Platelet parameters contributed mostly to depression prediction model. While, to random forest differential diagnosis model based on the data from depression and anxiety groups, prediction accuracy reached 0.68 and AUC 0.622. Age, platelet parameters, and average volume of red blood cells contributed the most to the model. In conclusion, the study researched on the prediction model of depression by exploring blood cell analysis parameters, revealing that machine learning models were more objective in the evaluation of mental illness.
