Incidence and related factors of antiviral drug resistance in HIV-infected pregnant and postpartum women in some areas of three western provinces of China from 2017 to 2019.
10.3760/cma.j.cn112150-20230213-00102
- VernacularTitle:2017—2019年我国西部三省部分地区HIV感染孕产妇抗病毒治疗药物耐药性发生及其相关因素分析
- Author:
He SUN
1
;
Ai Ling WANG
1
;
Jun YAO
2
;
Jia Rui ZHENG
3
;
Qing Hua QIN
4
;
Wu Li SHA
5
;
Xiao Yan WANG
1
;
Ya GAO
1
;
Zhen LI
1
;
Dong Xu HUANG
1
;
Qian WANG
1
Author Information
1. National Center for Women and Children's Health, Chinese Centers for Disease Control and Prevention, Beijing 100081, China.
2. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
3. Yunnan Provincial Maternal and Child Health Care Hospital, Kunming 650051, China.
4. Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital, Nanning 530000, China.
5. Xinjiang Maternal and Child Health Care Hospital, Urumqi 830000, China.
- Publication Type:Journal Article
- MeSH:
Female;
Humans;
Pregnancy;
HIV Infections/drug therapy*;
Incidence;
China/epidemiology*;
Infectious Disease Transmission, Vertical/prevention & control*;
Postpartum Period;
Drug Resistance, Viral/genetics*;
Antiviral Agents/therapeutic use*
- From:
Chinese Journal of Preventive Medicine
2023;57(11):1788-1793
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the incidence and related factors of drug resistance in HIV-infected pregnant and postpartum women in some areas of three western provinces of China from 2017 to 2019. Methods: From April 2017 to April 2019, face-to-face questionnaires and blood sample testing were conducted in all health care institutions providing maternal and perinatal care and midwifery-assisted services in 7 prevention of mother-to-child transmissi project areas in Xinjiang, Yunnan and Guangxi provinces/autonomous regions. Information was collected during the perinatal period and viral load, CD4+T lymphocytes and drug resistance genes were detected at the same time. The multivariate logistic regression model was used to analyze the relationship between different factors and drug resistance in HIV-infected pregnant and postpartum women. Results: A total of 655 HIV-infected pregnant and postpartum women were included in this study. The incidence of drug resistance was 3.4% (22/655), all of whom were cross-drug resistant. The rate of low, moderate and high drug resistance was 2.1% (14/655), 1.2% (8/655) and 0.8% (5/655), respectively. The drug resistance rate in the people who had previously used antiviral drugs was 1.9% (8/418), and the drug resistance rate in the people who had not used drugs was 5.9% (14/237). The NNRTI drug resistance accounted for 2.8% (18/655) and the NRTI drug resistance rate was 2.5% (16/655). The multivariate logistic regression model showed that the risk of HIV resistance was lower in pregnant women who had previously used antiviral drugs (OR=0.32, 95%CI: 0.11-0.76). Conclusion: Strengthening the management of antiviral drug use and focusing on pregnant and postpartum women who have not previously used antiviral drugs can help reduce the occurrence of drug-resistant mutations. Personalized antiviral therapy should be considered to achieve viral inhibition effects in clinical practice.
