The epidemiology and pathogeny investigation of two clusters of severe fever with thrombocytopenia syndrome disease outbreaking in Henan Province, 2022.
10.3760/cma.j.cn112150-20221130-01162
- Author:
Yi LI
1
;
Xiao Yang WANG
2
;
Ya Fei LI
1
;
Dong Xiao LI
1
;
Xiao HU
1
;
Lin ZHU
1
;
Ai Guo YOU
1
;
Hai Feng WANG
1
;
Ying YE
1
;
Wan Shen GUO
1
;
Xue Yong HUANG
1
Author Information
1. Henan Key Laboratory of Infectious Disease Microbiology/Infectious Disease Control and Prevention Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
2. Henan Key Laboratory of Infectious Disease Microbiology/Infectious Disease Control and Prevention Institute, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Severe Fever with Thrombocytopenia Syndrome/epidemiology*;
Bunyaviridae Infections/epidemiology*;
Thrombocytopenia/complications*;
Phlebovirus/genetics*;
Disease Outbreaks;
China/epidemiology*
- From:
Chinese Journal of Preventive Medicine
2023;57(10):1719-1724
- CountryChina
- Language:Chinese
-
Abstract:
To investigate two clusters of severe fever with thrombocytopenia syndrome virus (SFTSV) in Xinyang City, Henan Province, in 2022, and analyze their causes, transmission route, risk factors, and the characteristics of virus genetic variation. Case search and case investigation were carried out according to the case definition. Blood samples from cases, family members and neighbors and samples of biological vectors were collected for RT-PCR to detect SFTSV. The whole genome sequencing and bioinformatics analysis were performed on the collected positive samples. A total of two clustered outbreaks occurred, involving two initial cases and ten secondary cases, all of which were family recurrent cases. Among them, nine secondary cases had close contact with the blood of the initial case, and it was determined that close contact with blood was the main risk factor for the two clustered outbreaks. After genome sequencing analysis, we found that the SFTSV genotype in two cases was type A, which was closely related to previous endemic strains in Xinyang. The nucleotide sequence of the SFTSV in the case was highly homologous, with a total of nine amino acid mutation sites in the coding region. It was not ruled out that its mutation sites might have an impact on the outbreak of the epidemic.
