Further understanding and paying attention to normoalbuminuric diabetic kidney disease.
10.3760/cma.j.cn112150-20230404-00256
- Author:
Bi Tao WU
1
;
Na AN
1
;
Yu Wei YANG
1
;
Zheng hong HUANG
1
;
Jia Fu FENG
1
Author Information
1. Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621000, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Diabetic Nephropathies/etiology*;
Diabetes Mellitus, Type 2/complications*;
Albuminuria;
Kidney;
Proteinuria/complications*
- From:
Chinese Journal of Preventive Medicine
2023;57(10):1663-1673
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes mellitus (DM) has grown up to be an important issue of global public health because of its high incidence rate. Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease (ESKD). Therefore, early diagnosis and timely prevention and treatment of DKD are essential for the progress of DM. The clinical diagnosis and staging of DKD are mostly based on the urinary albumin excretion rate (UAER) and estimated glomerular filtration rate (eGFR). However, clinically, DKD patients show normoalbuminuric diabetic kidney disease (NADKD) instead of clinical proteinuria. The old NADKD concept is no longer suitable and should be updated accordingly with the redefinition of normal proteinuria by NKF/FDA (National Kidney Foundation/Food and Drug Administration). Based on the relevant guidelines of DM and chronic kidney disease (CKD) and combined with the current situation of clinical research, the review described NADKD from the aspects of epidemiology, pathological mechanism, disease diagnosis, clinical characteristics and biomarkers, to arouse the new understanding of NADKD in the medical profession and pay attention to it.
