The effects of nucleotide-binding oligomerization domain-like receptor 3 inflammasome on obstructive sleep apnea and its complications.
10.3760/cma.j.cn112150-20221120-01131
- Author:
Rui Kun WANG
1
;
Jie Qiong LIANG
1
;
Ying Xia LU
1
;
Xiao Jun ZHAN
1
;
Qing Long GU
1
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Children's Hospital Capital Institute of Pediatrics, Beijing 100020, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Inflammasomes;
Endothelial Cells;
NLR Family, Pyrin Domain-Containing 3 Protein;
Inflammation;
Sleep Apnea, Obstructive;
Nucleotides
- From:
Chinese Journal of Preventive Medicine
2023;57(9):1510-1516
- CountryChina
- Language:Chinese
-
Abstract:
Obstructive sleep apnea (OSA) is a sleep disorder with a high incidence and severe impact on the human body, which can induce systemic chronic inflammatory responses. Chronic inflammation is an important cause of exacerbation of OSA and its associated complications. Nucleotide-binding oligomerization domain-like receptor 3 (NLRP3) is an inflammasome that is widely found in epithelial cells and immune cells and plays an important role in inflammatory diseases as an important component of innate immunity. Research evidence suggests that the activation of NLRP3 inflammasomes can exacerbate the damage to neurons, endothelial cells, lung and kidney caused by OSA, and these effects can be eliminated by genetic or pharmacological deletion of NLRP3. Targeting inhibition of NLRP3 inflammasome may serve as a co-therapeutic strategy for OSA-induced related complications. This article reviews NLRP3 inflammasome and its mechanism in OSA-related concurrent diseases, which can provide scientific basis for prevention and intervention of OSA and its related complications.
