Maternal nutritional factors and environmental exposure in early life and childhood atopic dermatitis.
10.3760/cma.j.cn112150-20220930-00946
- VernacularTitle:生命早期母体营养和家庭环境暴露与子代特应性皮炎发病的研究进展
- Author:
Ying YE
1
;
Li Min DOU
1
;
Liu Hui WANG
1
Author Information
1. Department of Dermatology, Children's Hospital of Fudan University, Shanghai 201102, China.
- Publication Type:Journal Article
- MeSH:
Child;
Female;
Pregnancy;
Humans;
Dermatitis, Atopic;
Quality of Life;
Environmental Exposure/adverse effects*;
Maternal Exposure/adverse effects*;
Family
- From:
Chinese Journal of Preventive Medicine
2023;57(9):1489-1496
- CountryChina
- Language:Chinese
-
Abstract:
Atopic dermatitis(AD)is a chronic, recurrent, inflammatory skin disease in children. The disease is characterized by dryness, chronic eczema-like lesions and obvious itching, seriously affecting the quality of life of children and their families. The pathogenesis of AD is not yet to be clear, and it might be the interaction of genetic susceptibility and environmental exposure to induce skin barrier impairment and immune system dysfunction. In recent years, the role of maternal factors or intrauterine environment exposure on childhood allergic diseases has been attracted attention, and the hypothesis that allergic diseases originate from the fetal period has been postulated. Maternal exposures called "early life exposure", such as nutritional factors during pregnancy (folate, vitamin D, vitamin E and polyunsaturated fatty acid) and tobacco exposure, home environmental exposure may be related with childhood atopic dermatitis. This article would focus on the recent research about maternal nutritional factors and family environmental exposure during pregnancy on offspring's atopic dermatitis.
