Application of novel non-endoscopic device in the screening and early diagnosis of esophageal cancer.
10.3760/cma.j.cn112152-20220516-00337
- VernacularTitle:食管新型细胞收集器在食管癌筛查与早期诊断中的应用
- Author:
Zhi Yuan FAN
1
;
Ru CHEN
1
;
Wen qiang WEI
1
Author Information
1. Office for Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
- Publication Type:Journal Article
- Keywords:
Biomarker;
Early diagnosis;
Esophageal neoplasms;
Novel non-endoscopic device;
Screening
- MeSH:
Humans;
Esophageal Neoplasms/pathology*;
Early Detection of Cancer;
Esophageal Squamous Cell Carcinoma;
Barrett Esophagus/pathology*;
Biomarkers/analysis*;
Esophagoscopy
- From:
Chinese Journal of Oncology
2023;45(8):637-641
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal cancer (EC) is a dreadful disease with a poor prognosis and poses heavy health burden worldwide. Developing effective methods to identify high-risk individuals is urgently needed for preliminary screening before endoscopy. The novel non-endoscopic device has the potential advantages of low cost, simple operation, and minimal invasiveness. Approximately 90% of participants can swallow the device successfully with high safety profiles, and sufficient esophageal exfoliated cells can be collected for cytological examination and biomarker detection. Cytological examination based on the device combined with trefoil factor 3 (TFF3) protein or DNA methylation examinations could effectively screen Barrett's esophagus-associated dysplasia and early esophageal adenocarcinoma, but large prospective studies are needed to further validate the diagnostic value of this device to improve the quality of evidence. Although the device-based cytological examination in combination with biomarker detection holds promise in the early screening of esophageal squamous dysplasia and early esophageal squamous cell carcinoma, related research is still in its infancy, and there is still a lack of sufficient evidence for population screening in China. Active research into the application of this novel non-endoscopic device in EC screening and early diagnosis is of great significance for optimizing EC screening strategies and improving the early diagnosis of EC.
