The association between body mass index and in-hospital major adverse cardiovascular and cerebral events in patients with acute coronary syndrome
10.3760/cma.j.cn112148-20230915-00165
- VernacularTitle:体重指数与急性冠脉综合征患者院内不良心脑血管事件的相关性
- Author:
Qing ZHOU
1
;
Dan ZHU
;
Yiting WANG
;
Wenyue DONG
;
Jie YANG
;
Jun WEN
;
Jun LIU
;
Na YANG
;
Dong ZHAO
;
Xinwei HUA
;
Yida TANG
Author Information
1. 中国医学科学院 北京协和医学院 国家心血管病中心 阜外医院冠心病中心，北京 100037
- Keywords:
Acute coronary syndrome;
Body mass index;
Prognosis
- From:
Chinese Journal of Cardiology
2024;52(1):42-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the association between body mass index (BMI) and major adverse cardiovascular and cerebrovascular events (MACCE) among patients with acute coronary syndrome (ACS).Methods:This was a multicenter prospective cohort study, which was based on the Improving Care for Cardiovascular Disease in China (CCC) project. The hospitalized patients with ACS aged between 18 and 80 years, registered in CCC project from November 1, 2014 to December 31, 2019 were included. The included patients were categorized into four groups based on their BMI at the time of admission: underweight (BMI<18.5 kg/m 2), normal weight (BMI between 18.5 and 24.9 kg/m 2), overweight (BMI between 25.0 and 29.9 kg/m 2), and obese (BMI≥30.0 kg/m 2). Multivariate logistic regression models was used to analyze the relationship between BMI and the risk of in-hospital MACCE. Results:A total of 71 681 ACS inpatients were included in the study. The age was (63.4±14.7) years, and 26.5% (18 979/71 681) were female. And the incidence of MACCE for the underweight, normal weight, overweight, and obese groups were 14.9% (322/2 154), 9.5% (3 997/41 960), 7.9% (1 908/24 140) and 7.0% (240/3 427), respectively ( P<0.001). Multivariate logistic regression analysis showed a higher incidence of MACCE in the underweight group compared to the normal weight group ( OR=1.30, 95% CI 1.13-1.49, P<0.001), while the overweight and obese groups exhibited no statistically significant difference in the incidence of MACCE compared to the normal weight group (both P>0.05). Conclusion:ACS patients with BMI below normal have a higher risk of in-hospital MACCE, suggesting that BMI may be an indicator for evaluating short-term prognosis in ACS patients.
