The association between body mass index and in-hospital major adverse cardiovascular and cerebral events in patients with acute coronary syndrome.
10.3760/cma.j.cn112148-20230915-00165
- Author:
Qing ZHOU
1
;
Dan ZHU
2
;
Yi Ting WANG
2
;
Wen Yue DONG
2
;
Jie YANG
2
;
Jun WEN
2
;
Jun LIU
3
;
Na YANG
3
;
Dong ZHAO
3
;
Xin Wei HUA
2
;
Yi Da TANG
2
Author Information
1. Department of Cardiology, Fuwai Hospital and Cardiovascular Institute, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
2. Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases, Chinese Academy of Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, National Health Commission Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100191, China.
3. Center of Clinical and Epidemiology Researches, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Female;
Adolescent;
Young Adult;
Adult;
Middle Aged;
Aged;
Aged, 80 and over;
Male;
Body Mass Index;
Overweight/complications*;
Acute Coronary Syndrome;
Thinness/epidemiology*;
Prospective Studies;
Risk Factors;
Obesity/complications*;
Hospitals
- From:
Chinese Journal of Cardiology
2024;52(1):42-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To assess the association between body mass index (BMI) and major adverse cardiovascular and cerebrovascular events (MACCE) among patients with acute coronary syndrome (ACS). Methods: This was a multicenter prospective cohort study, which was based on the Improving Care for Cardiovascular Disease in China (CCC) project. The hospitalized patients with ACS aged between 18 and 80 years, registered in CCC project from November 1, 2014 to December 31, 2019 were included. The included patients were categorized into four groups based on their BMI at the time of admission: underweight (BMI<18.5 kg/m2), normal weight (BMI between 18.5 and 24.9 kg/m2), overweight (BMI between 25.0 and 29.9 kg/m2), and obese (BMI≥30.0 kg/m2). Multivariate logistic regression models was used to analyze the relationship between BMI and the risk of in-hospital MACCE. Results: A total of 71 681 ACS inpatients were included in the study. The age was (63.4±14.7) years, and 26.5% (18 979/71 681) were female. And the incidence of MACCE for the underweight, normal weight, overweight, and obese groups were 14.9% (322/2 154), 9.5% (3 997/41 960), 7.9% (1 908/24 140) and 7.0% (240/3 427), respectively (P<0.001). Multivariate logistic regression analysis showed a higher incidence of MACCE in the underweight group compared to the normal weight group (OR=1.30, 95%CI 1.13-1.49, P<0.001), while the overweight and obese groups exhibited no statistically significant difference in the incidence of MACCE compared to the normal weight group (both P>0.05). Conclusion: ACS patients with BMI below normal have a higher risk of in-hospital MACCE, suggesting that BMI may be an indicator for evaluating short-term prognosis in ACS patients.
