Research progress in STAT3/Th17 cells and Sj?gren syndrome
10.11665/j.issn.1000-5048.2023041805
- VernacularTitle:STAT3/Th17细胞与干燥综合征的研究进展
- Author:
Jiang WANG
1
;
Xueyan ZHAO
;
Weirong FANG
Author Information
1. 中国药科大学基础医学与临床药学学院,江苏 210009
- Keywords:
Sj?gren syndrome;
STAT3;
Th17;
autoimmune diseases;
STAT3 inhibitor
- From:
Journal of China Pharmaceutical University
2024;55(3):420-428
- CountryChina
- Language:Chinese
-
Abstract:
Signal transducer and activator of transcription 3(STAT3)is an intracellular signaling factor that plays a critical role in various cellular processes,including the growth,differentiation,apoptosis,and immune response of cells.Aberrant activation of T helper cell 17(Th17)is closely associated with the morbidity and progress of various autoimmune diseases.STAT3 participates in the pathogenesis of Sj?gren syndrome by inducing excessive proliferation and abnormal differentiation of Th17 cells and affecting lymphocyte infiltration into exocrine glands.Therefore,targeting the STAT3 signaling pathway represents a potential novel therapeutic approach for the treatment of Sj?gren syndrome.This review summarizes the research of STAT3 in the pathogenesis and progression of Sj?gren syndrome through regulating Th17 cells,focusing on current inhibitors targeting the STAT3 signaling pathway as potential therapeutic targets for Sj?gren syndrome.
