Advances in the application of artificial intelligence in nucleic acid drug development
10.11665/j.issn.1000-5048.2024033101
- VernacularTitle:人工智能在核酸药物研发中的应用和进展
- Author:
Zi’ang HU
1
;
Liming GAO
;
Wenying YU
Author Information
1. 中国药科大学孟目的学院
- Publication Type:Journal Article
- Keywords:
artificial intelligence / nucleic acid drugs / nucleic acid database / nucleic acid characterization / nucleic acid structure prediction / small nucleic acid drug design
- From:
Journal of China Pharmaceutical University
2024;55(3):335-346
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: In recent years, the field of nucleic acid therapeutics has been flourishing, progressively establishing itself as the third generation of drug modalities following small molecules and antibody-based drugs. Artificial intelligence technology based on machine learning is advancing rapidly, which can significantly accelerate the development process of nucleic acid therapeutics. This review provides an overview of the foundational aspects of artificial intelligence algorithms, databases, and characterizations in the field of nucleic acid drug development. It elucidates the advances in the application of artificial intelligence in nucleic acid structural prediction, small nucleic acid drug design, and other research and development phases of nucleic acid therapeutics, aiming to offer some reference for the interdisciplinary development of artificial intelligence and nucleic acid drugs.
