No Association between DRD2 polymorphism Ser311/Cys311 and Bipolar Disorder in Korean Population.
- Author:
Tong Wook HUR
1
;
Ik Seung CHEE
;
Young Ho LEE
Author Information
1. Hur's Neuropsychiatric Clinic, Cheon-Ahn, Chungnam, Korea.
- Publication Type:Original Article
- Keywords:
Bipolar disorder;
DRD2 gene;
Ser311/Cys311 polymorphism
- MeSH:
Bipolar Disorder*;
Gene Frequency;
Genotype;
Polymerase Chain Reaction;
Receptors, Dopamine D2
- From:Journal of Korean Neuropsychiatric Association
1999;38(6):1488-1493
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was designed to investigate the association between Ser311/Cys311 polymorphism in the dopamine D2 receptor gene and bipolar disorder in korean population. METHOD: Ser311/Cys311 polymorphism in the dopamine D2 receptor gene was typed with PCR in 86 bipolar disorders and 100 normal controls. RESULTS: Genotype of Ser/Ser, Ser/Cys, Cys/Cys were 82 (95.3%), 4 (4.7%), 0 (0.0%) respectively in the bipolar disorders, 96 (96.0%), 4 (4.0%), 0 (0.0%) respectively in the controls. Allele frequencies of Ser and Cys were 168 (97.7%), 4 (2.3%) in the bipolar disorders, 196 (98.0%), 4 (2.0%) in the controls. There were no differencies in genotype distribution and allele frequencies of dopamine D2 receptor gene polymorphism Ser311/Cys311 between in the bipolar disorders and in the controls. CONCLUSION: These result suggests dopamine D2 receptor gene polymorphism Ser311/Cys311 is not causally related to the development of bipolar disorder in korean population.
