The Main Mechanisms of Mesenchymal Stem Cell-Based Treatments against COVID-19
10.1007/s13770-024-00633-5
- Author:
Jinling LI
1
;
Shipei HE
;
Hang YANG
;
Lizeai ZHANG
;
Jie XIAO
;
Chaoyi LIANG
;
Sijia LIU
Author Information
1. Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application CoConstructed by the Province and Ministry, Guangxi Key Laboratory of Regenerative Medicine and Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education, Guangxi Medical University, Shuangyong Road, Nanning 530021, Guangxi, People’s Republic of China
- Publication Type:REVIEW ARTICLE
- From:
Tissue Engineering and Regenerative Medicine
2024;21(4):545-556
- CountryRepublic of Korea
- Language:EN
-
Abstract:
BACKGROUND:Coronavirus disease 2019 (COVID-19) has a clinical manifestation of hypoxic respiratory failure and acute respiratory distress syndrome. However, COVID-19 still lacks of effective clinical treatments so far. As a promising potential treatment against COVID-19, stem cell therapy raised recently and had attracted much attention. Here we review the mechanisms of mesenchymal stem cell-based treatments against COVID-19, and provide potential cues for the effective control of COVID-19 in the future.
METHODS:Literature is obtained from databases PubMed and Web of Science. Key words were chosen for COVID- 19, acute respiratory syndrome coronavirus 2, mesenchymal stem cells, stem cell therapy, and therapeutic mechanism. Then we summarize and critically analyze the relevant articles retrieved.
RESULTS:Mesenchymal stem cell therapy is a potential effective treatment against COVID-19. Its therapeutic efficacy is mainly reflected in reducing severe pulmonary inflammation, reducing lung injury, improving pulmonary function, protecting and repairing lung tissue of the patients. Possible therapeutic mechanisms might include immunoregulation, antiinflammatory effect, tissue regeneration, anti-apoptosis effect, antiviral, and antibacterial effect, MSC - EVs, and so on.
CONCLUSION:Mesenchymal stem cells can effectively treat COVID-19 through immunoregulation, anti-inflammatory, tissue regeneration, anti-apoptosis, anti-virus and antibacterial, MSC - EVs, and other ways. Systematically elucidating the mechanisms of mesenchymal stem cell-based treatments for COVID-19 will provide novel insights into the follow-up research and development of new therapeutic strategies in next step.
